J Korean Soc Coloproctol.
2011 Oct;27(5):266-269. 10.3393/jksc.2011.27.5.266.
Oxaliplatin-induced Pulmonary Fibrosis: Two Case Reports
- Affiliations
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- 1Department of Surgery, Colorectal Cancer Center, Konkuk University Medical Center, Konkuk University School of Medicine, Seoul, Korea. hwangcrc@kuh.ac.kr
- KMID: 2198740
- DOI: http://doi.org/10.3393/jksc.2011.27.5.266
Abstract
- Oxaliplatin with infusional 5-fluorouracil plus leucovorin (FOLFOX regimen) is the one of the standard chemotherapy regimens for treating a colorectal carcinoma. The most common side effects include neutropenia, diarrhea, vomiting and peripheral neuropathy, and these are moderate and manageable. However, pulmonary toxicity is rarely reported to be associated with the FOLFOX regimen. Moreover, there is no established guideline for the management of this side effect. Here, along with a literature review, we report two cases of rapidly developing pulmonary fibrosis related to the use of the FOLFOX regimen in patients with colorectal carcinomas.
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