J Korean Soc Ther Radiol.  1994 Jun;12(2):143-150.

Pathologic Changes in the Rabbit lung Following Single Dose irradiation

• Lee HS
• Choi YM
• Hur WJ
• Jeong JS
• Yuh YH
• Lee KN

Abstract

The damage which radiation produces in tissues such as the lungs can be discussed at the molecular, biophysical, cellular, and organ levels. The cellular effects of irradiating the lungs are related to the histologic and clinical sequelae. In the present study the right lung of rabbits were exposed to single dose of 20 Gy of X-irradiation. Animals from each group were sacrificed monthly for 6 months postexposure. Sections of lung were examined by light microscopy(LM) and by transmission electron microscopy(TEM). Multiple exudative lesions were seen at 2 months after the 20Gy irradiation, and they progressed to a proliferative and then reparative fibrotic lesion by 6 months. Changes in epithelial lining of lung components, particulary the presence of type II pneumocytes were found by both LM and TEM. Capillary endothelial damages were less pronounced. The possible implication of cellular components in radiation pneumonitis and fibrosis is discussed.

Keyword

Radiation pneumonitis; fibrosis; rabbit

MeSH Terms

Animals
Capillaries
Fibrosis
Lung*
Pneumocytes
Rabbits
Radiation Pneumonitis