J Korean Med Assoc.  2009 Oct;52(10):963-974. 10.5124/jkma.2009.52.10.963.

Drug Therapy for Breast Cancer

• Park YH

• KMID: 2188078
• DOI: http://doi.org/10.5124/jkma.2009.52.10.963

Abstract

Breast cancer is the second common cancer and the leading cause of cancer deaths in women in Korea. Contrary to public perception, it is a heterogeneous disease with varying morphology, prognosis, and response to therapy. Understanding of the tumor biology results in marked advance in drug therapy proceeding to individualized molecular targeted therapy using predictive biomarkers (hormonal receptor: HR and human epidermal growth factor receptor -2: HER2). This review considers various drug therapeutic options based on biologic background of breast cancer divided into metastatic, neoadjuvant, and adjuvant systemic drug therapies. These are conventional cytotoxic chemotherapy, hormonal therapy, and molecular targeted therapies including trastuzumab, an anti-HER2 monoclonal antibody. In addition, bisphosphonate to improve outcomes of bone metastasis has seen an increased usage in adjuvant and metastatic setting. Microarray based genomic, transcription, and proteomic methods are transforming classification systems and identifying novel targets for the development of new therapeutics. It is important for us to appreciate and embrace the new developments as they will impact on daily clinical practice and require understanding of biomarkers as a tool for the determination of treatment options.

Keyword

Breast cancer; Chemotherapy; Hormone receptor; HER2; Molecular targeted therapy

MeSH Terms

Antibodies, Monoclonal, Humanized
Biomarkers
Biology
Breast
Breast Neoplasms
Female
Humans
Korea
Molecular Targeted Therapy
Neoplasm Metastasis
Prognosis
Receptor, Epidermal Growth Factor
Trastuzumab
Antibodies, Monoclonal, Humanized
Receptor, Epidermal Growth Factor

Figure

• 

  Figure 1 Integration of novel targeted therapies into the systemic treatment of breast cancer.

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