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Cooperative Subtype Switch of Thyroid Hormone Receptor and Nuclear Receptor Corepressor Related Epithelial–Mesenchymal Transition in Papillary Thyroid Cancer

Jeong S, Lee SG, Kim H, Lee G, Park S, Kim IK, Lee J, Jo YS

Background and Objectives: Although thyroid hormones affect human cancer progression, the regulatory mechanism of thyroid hormone receptors in carcinogenesis has not been elucidated. This study aimed to evaluate the expression...
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Association of single-nucleotide polymorphisms in the ESR2 and FSHR genes with poor ovarian response in infertile Jordanian women

Sindiani AM, Batiha O, Al-zoubi E, Khadrawi S, Alsoukhni G, Alkofahi A, Alahmad NA, Shaaban S, Alshdaifat E, Abu-Halima M

Objective: Poor ovarian response (POR) refers to a subnormal follicular response that leads to a decrease in the quality and quantity of the eggs retrieved after ovarian stimulation during assisted...
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Clinical Implications of Serum 25-Hydroxyvitamin D Status after 5-Year Adjuvant Endocrine Therapy for Late Recurrence of Hormone Receptor-positive Breast Cancer

Lim ST, Jeon YW, Gwak H, Suh YJ

Purpose: The prognostic implications of serum vitamin D status after a 5-year adjuvant endocrine therapy on the risk of late recurrence among hormone receptor (HR)-positive breast cancer patients remain unclear....
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Elevated Expression of RIOK1 Is Correlated with Breast Cancer Hormone Receptor Status and Promotes Cancer Progression

Huang Z, Li X, Xie T, Gu C, Ni K, Yin Q, Cao X, Zhang C

Purpose RIOK1 has been proved to play an important role in cancer cell proliferation and migration in various types of cancers—such as colorectal and gastric cancers. However, the expression of RIOK1...
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Thyroid Hormone Resistance in a Preterm Infant with a Novel THRB Mutation

Bae JY, Kim DY, Kwon YD, Song YH, Lim HH, Park HD, Lim JW

Resistance to thyroid hormone (RTH) is a condition caused by a mutation in the thyroid hormone receptor gene. It is rarely reported in individuals with no family history of RTH...
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Laboratory Testing in Thyroid Conditions - Pitfalls and Clinical Utility

Soh SB, Aw TC

Thyroid disorders are common, affecting more than 10% of people in the US, and laboratory tests are integral in the management of these conditions. The repertoire of thyroid tests includes...
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A Case with Thyroid Hormone Resistance Syndrome

Lee H, Lee J, Lee DH

Thyroid hormone resistance is a rare syndrome of reduced tissue responsiveness to thyroid hormone. We report the case of a 13-month girl with short height and low weight. She was...
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Hyponatremia in Liver Cirrhosis

Jang C, Jung YK

Hyponatremia is a commonly observed complication that is related to hypoalbuminemia and portal hypertension in patients with advanced liver cirrhosis. Hyponatremia in patients with liver cirrhosis is mostly dilutional hyponatremia...
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Risk Factors for Structural Changes in Meibomian Gland in Thyroid Eye Disease

Kim M, Yang S, Park J, Lee H, Baek S

PURPOSE: To investigate the effect of clinical activity score (CAS) and thyroid stimulating hormone receptor autoantibody (TSHR autoantibody) on structural changes in Meibomian gland in patients with thyroid eye disease...
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The expression of Müllerian inhibiting substance/anti-Müllerian hormone type II receptor in myoma and adenomyosis

Kim SY, Moon HM, Lee MK, Chung YJ, Song JY, Cho HH, Kim MR, Kim JH

OBJECTIVE: We compared the expression levels of Müllerian inhibiting substance (MIS)/anti-Müllerian hormone type II receptor (AMHRII) in uterine myoma and adenomyosis to evaluate the possibility of using MIS/anti-Müllerian hormone (AMH)...
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Efficacy of Letrozole as First-Line Treatment of Postmenopausal Women with Hormone Receptor–Positive Metastatic Breast Cancer in Korea

Beom SH, Oh J, Kim TY, Lee KH, Yang Y, Suh KJ, Moon HG, Han SW, Oh DY, Han W, Kim TY, Noh DY, Im SA

PURPOSE: Letrozole showed efficacy and generally favorable toxicities, along with the convenience of oral administration in postmenopausal patients with hormone receptor (HR)–positive metastatic breast cancer (MBC). To the best of...
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Oncologic Effect of Oral Fluorouracil in Hormone Receptor-Negative T1a Node-Negative Breast Cancer Patients

Kim M, Ahn S, Son B, Lee J, Koh B, Sohn B, Lee S, Kim HJ

PURPOSE: As 5-fluorouracil (5-FU) has previously exhibited antitumor activity and few adverse effects in the treatment of breast cancer, we aimed to specifically assess the benefits of orally administered 5-FU...
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Comparison of Patient Characteristics in Thyroid-Associated Ophthalmopathy with and without Strabismus

Choi KJ, Kim SH, Lee JY

PURPOSE: To determine immunochemical and clinical differences in thyroid-associated ophthalmopathy (TAO) patients with restrictive strabismus and without strabismus. METHODS: A retrospective chart review of 15 TAO patients with strabismus (25 eyes)...
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Association between the Growth Hormone Receptor Exon 3 Polymorphism and Metabolic Factors in Korean Patients with Acromegaly

Park HY, Hwang IR, Seo JB, Kim SW, Seo HA, Lee IK, Kim JG

BACKGROUND: This study investigated the association between the frequency of growth hormone receptor (GHR) exon 3 polymorphism (exon 3 deletion; d3-GHR) and metabolic factors in patients with acromegaly in Korea. METHODS:...
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Triple-negative breast cancer that progressed as estrogen receptor-positive skin metastases

Lee SM, Kang EJ, Kim JH, Yun JM, Sun DS, Ko YH, Won HS

No abstract available.
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Resistance to thyroid hormone due to a novel mutation of thyroid hormone receptor beta gene

Lee JH, Kim EY

Resistance to thyroid hormone (RTH) is a rare inherited syndrome characterized by diminished response of the target tissue to thyroid hormone caused, in the majority of cases, by mutation of...
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Clinical Significance of Age at the Time of Diagnosis among Young Breast Cancer Patients

Kim IK, Park S, Hwang H, Lee JS, Ko SM, Kim SI, Park BW

PURPOSE: The aims of this study were to investigate outcomes corresponding to age at diagnosis as categorized into 5-year intervals and to explore whether endocrine-responsive tumors display clinical benefits from...
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Ultrasound and Clinicopathological Characteristics of Triple Receptor-Negative Breast Cancers

Choi YJ, Seong MH, Choi SH, Kook SH, Kwag HJ, Park YL, Park CH

PURPOSE: Triple receptor-negative (TRN) breast cancer is associated with high risk of recurrence and poor prognosis. The present study assessed the clinicopathologic characteristics and ultrasound (US) features of TRN breast...
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Case of Thyroid Hormone Resistance Syndrome with a Mutation in the Thyroid Hormone Receptor Beta Gene

Lim SK, Kim SY, Kang JG, Kim CS, Ihm SH, Yoo HJ, Lee SJ

  • KMID: 2258892
  • Korean J Med.
  • 2011 Jun;80(Suppl 2):S220-S226.
In thyroid hormone resistance syndrome (THR) TSH levels are normal or elevated despite thyroid hormone levels being elevated. THR is distinguished from TSH-producing pituitary adenoma by TRH stimulation and alpha-subunit...
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Association Between Thyroid Associated Ophthalmopath and Thyroid Autoantibody

Hwang DJ, Kim YJ

PURPOSE: The same autoimmune process is thought to cause thyroid associated ophthalmopathy (TAO) and Graves' disease. The aim of this study is to determine hether thyroid autoantibody is related to...
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