J Korean Neurol Assoc.  1999 Nov;17(6):810-815.

Cortical Dysplasia and Mesial Temporal Sclerosis in Temporal Lobe Epilepsy Pre-operative Clinical Feature and Surgical Outcome between Patients with Dual Pathology and Patients with Mesial Temporal Sclerosis

• Kang SY
• Kang JK
• Ma HI
• Kwak KH
• Lee JK
• Park SH
• Khang SK
• Lee SA

Abstract

BACKGROUND: Mesial temporal sclerosis (MTS) is a well-known cause of temporal lobe epilepsy. Coexistence with cortical dysplasia (CD) has been reported, but its role is not well recognized. This study aims to determine whether there is any difference about clinical feature and surgical outcome between patients with MTS and coexistent CD (group 1) and patients with isolated MTS (group 2).
METHODS
Retrospectively, surgical series of 45 patients (male:22, female:23) diagnosed as temporal lobe epilepsy were reviewed. We excluded patients who had another pathology (e. g., tumor, vascular malformation) except MTS or CD. The pathology, case histories, interictal EEG, and surgical outcome were compared.
RESULTS
There was a tendency for group 1 patients to have earlier seizure onset age (10.9+/-6.35 versus 14.5+/-6.03, p=0.06) There was no statistically significant difference in the history of febrile convulsions (68.4% versus 53.8%, p>0.16) No statistically significant difference between groups were also found in disease duration, the head trauma/mental retardation history, seizure frequency, interictal EEG, and surgical outcome.
CONCLUSIONS
CD in MTS appears to have an influence on seizure onset. The relationships among CD, febrile convulsion, and mesial temporal sclerosis must be more investigated.

Keyword

Cortical dysplasia; Temporal lobe epilepsy; Dual pathology and mesial temporal sclerosis; Febrile convulsion; Seizure onset; Surgical outcome

MeSH Terms

Age of Onset
Electroencephalography
Epilepsy, Temporal Lobe*
Head
Humans
Malformations of Cortical Development*
Pathology*
Retrospective Studies
Sclerosis*
Seizures
Seizures, Febrile
Temporal Lobe*