Chonnam Med J.  2000 Sep;36(3):291-295.

Magnetization Transfer Imaging for Detection of Mesial Temporal Sclerosis in Temporal Lobe Seizure

Affiliations
  • 1Department of Diagnostic Radiology, Chonnam National University Medical School, Kwangju, Korea.
  • 2Department of Radiology, University of Washington School of Medicine Seattle, Washington, USA.
  • 3Department of Neurological Surgery, University of Washington School of Medicine Seattle, Washington, USA.

Abstract

We evaluated the usefulness of magnetization transfer imaging for detection of mesial temporal sclerosis with temporal lobe seizure. Eighteen patients underwent MR imaging and histologically confirmed by operation were evaluated retrospectively. Twenty-seven normal control volunteers underwent MR imaging. Pixel-by-pixel MTR maps were reconstructed and quantitative MTR values were obtained. We calculated normalize the MTR values by dividing the MTR value of the hippocampus by the MTR value of adjacent temporal lobe white matter on each side. Normalized MTR values for the control population ranged between 0.63 and 0.79, resulted in approximately 40% suppression of signal from normal white matter. Normalized MTR values for the control population showed narrow range of distribution. Fifteen patients in this series with good quality MT images had histologically proven mesial temporal sclerosis. The lowest normal MTR value was 0.41. In comparison, the abnormal hippocampi with mesial temporal sclerosis tended to show lower normalized MT values. Additionally, the patients with more severe changes of mesial temporal sclerosis on histological examination tended to have lower MTR values than those patients that had minimal or no changes of hippocampi. When we regarded it abnormal if normalized MTR value was lower than 0.62, the 3 patients were false negative. Magnetization transfer imaging is new MR techniques that has improved sensitivity in the detection and lateralization of mesial temporal sclerosis with temporal lobe epilepsy and also it can provide quantitative information on tissue structure.

Keyword

Brain, MR; Brain, MR spectroscopy; Brain, temporal lobe epilepsy

MeSH Terms

Epilepsy, Temporal Lobe
Hippocampus
Humans
Magnetic Resonance Imaging
Retrospective Studies
Sclerosis*
Seizures*
Temporal Lobe*
Volunteers
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