J Korean Fract Soc.  2004 Apr;17(2):197-201. 10.12671/jkfs.2004.17.2.197.

Clinical Applications of Autologous Cultured Osteoblasts: Case Report

• Kim SJ
• Ok IY
• Chang CH
• Kim YS
• Jang JD
• Bahk WJ
• Lee JH

• KMID: 2184068
• DOI: http://doi.org/10.12671/jkfs.2004.17.2.197

Abstract

We treated 3 cases of fracture and 1 case of avascular necrosis of femoral head using autologous cultured osteoblasts injection. The stromal cells from the bone marrow were cultured to differentiate to osteoblasts for 4 weeks. The fracture sites of each patients were right ulnar shaft, left radial shaft, and left 5th metatarsal base. All of the fractures showed callus formations after 1 week of osteoblasts injection to the fracture site. After 4 weeks, callus formations were progressed. Avascular necrosis of femoral head was bilateral and both were Ficat stage II. Core decompression and allograft impaction were performed to the left, and core decompression and autologous cultured osteoblasts injection percutaneously after 4 weeks of the decompression operation were done to the right femoral head. CT images of 1 year from the operations showed trabecular bone formation and well maintained femoral head contour of the right femur, but resorption of the grafted bone for the left.

Keyword

Autologous cultured osteoblasts injection; Avascular necrosis of femoral head; Fracture

MeSH Terms

Allografts
Bone Marrow
Bony Callus
Decompression
Femur
Head
Humans
Metatarsal Bones
Necrosis
Osteoblasts*
Osteogenesis
Stromal Cells
Transplants