J Korean Knee Soc.  2005 Dec;17(2):241-245.

The Effect of Aprotinin for Reducing Blood Loss and Amount of Transfusion in Total Knee Arthroplasty

• Choi YJ
• Hwang JK
• Ahn HS
• Bae EJ
• Kim CH
• Kim E

Abstract

PURPOSE: To evaluate the effect of Aprotinin in reducing postoperative blood loss and amount of transfusion in total knee arthroplasty.
MATERIALS AND METHODS
In a prospective study, 100 patients undergoing bilateral total knee arthroplasty were investigated. A low dose Aprotinin was administred in randomly selected fifty patients and the other fifty patients were selected as control group. Postoperative blood loss, the amount of intraoperative and postoperative transfusion, preoperative and postoperative value of hemoglobin and hematocrit were evaluated and statiscally compared. Postoperative complications were assessed.
RESULTS
Significant reduction in postoperative total blood loss was observed (Aprotinin group:1195 ml, control group:2216 ml). The amount of packed red blood cells transfusion was also reduced in Aprotinin group (Aprotinin group: 2.0 units, control group: 4.0 units), and fresh frozen plasma (Aprotinin group: 0.1units, control group: 1.2 units) as well. Aprotinin also reduced the decline in hemoglobin and hematocrit levels at the first, second and fourth postoperative days. There were no clinical evidence of complications such as anaphylactic shock, deep vein thrombosis, thromboembolism, myocardiac infarction and acute renal failure.
CONCLUSION
Aprotinin is safe and effective in reducing postoperative blood loss and amount of blood transfusion in total knee arthroplasty.

Keyword

Total knee arthroplasty; Aprotinin; Postoperative blood loss and transfusion

MeSH Terms

Acute Kidney Injury
Anaphylaxis
Aprotinin*
Arthroplasty*
Blood Transfusion
Erythrocytes
Hematocrit
Humans
Infarction
Knee*
Plasma
Postoperative Complications
Postoperative Hemorrhage
Prospective Studies
Thromboembolism
Venous Thrombosis
Aprotinin