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Heme Oxygenase-1 Induced by Aprotinin Inhibits Vascular Smooth Muscle Cell Proliferation Through Cell Cycle Arrest in Hypertensive Rats

Choi HC, Lee KY, Lee DH, Kang YJ

Spontaneous hypertensive rats (SHR) are an established model of genetic hypertension. Vascular smooth muscle cells (VSMC) from SHR proliferate faster than those of control rats (Wistar-Kyoto rats; WKY). We tested...
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Aprotinin Inhibits Vascular Smooth Muscle Cell Inflammation and Proliferation via Induction of HO-1

Lee DH, Choi HC, Lee KY, Kang YJ

Aprotinin is used clinically in cardiopulmonary bypass surgery to reduce transfusion requirements and the inflammatory response. The mechanism of action for the anti-inflammatory effects of aprotinin is still unclear....
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The Effect of Low Dose Aprotinin in Patients with Adolescent Idiopathic Scoliosis Undergoing Posterior Spinal Fusion

Park HG, Yoo BH, Lee S, Yon JH, Hong KH

  • KMID: 2263297
  • Anesth Pain Med.
  • 2008 Jul;3(3):178-182.
BACKGROUND: Aprotinin is a kallikrein inhibitor at high doses and a plasmin inhibitor at low doses. Low-dose aprotinin has been shown to reduce transfusion requirements in patients undergoing liver resection,...
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Two Cases of Acute Renal Failure Associated with Aprotinin

Yun YS, Kwon SH, Park EK, Jeon JS, Noh HJ, Han DC, Jin SY

  • KMID: 2253282
  • Korean J Nephrol.
  • 2008 May;27(3):383-388.
Aprotinin is a nonspecific serine protease inhibitor and antifibrinolytic agent. It has been used to control bleeding and reduce the amounts of transfusion during the perioperative period. There are few...
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The Effect of Paratendinous Aprotinin Injection in Patients with Rotator Cuff Tendinitis

Jung H, Seo JH, Ko MH, Sim YJ

  • KMID: 2136462
  • J Korean Acad Rehabil Med.
  • 2008 Feb;32(1):56-61.
OBJECTIVE: To determine the therapeutic effect of paratendinous injection of aprotinin, a polyvalent inhibitor of inflammatory proteolytic enzyme, in patients with shoulder tendinitis. METHOD: Thirty patients with shoulder tendinitis diagnosed with...
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Effect of Aprotinin on Uncontrolled Hemorrhage After Splenic Injury Model in Rats

Sung W, Yim H, Cho B, Lee J, Yang H, Yang Y, Hong S

  • KMID: 1837058
  • J Korean Soc Emerg Med.
  • 2007 Oct;18(5):359-366.
PURPOSE: We investigated the effect of the protease inhibitor, aprotinin, on mean arterial pressure (MAP), hematocrit (Hct), blood loss, and survival rate in rats with experimental splenic injury. METHODS: We created...
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Intraoperative Anaphylactoid Reaction Related to Aprotinin after Local Application of Fibrin Glue in Transsphenoid Surgery : A case report

Jeon SS, Choi YW

Recently fibrin glue, a hemostatic or adhesive material has been used worldwide in surgical procedures. There have been only limited numbers of reports on anaphylaxis following the topical use of...
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Aprotinin Reduced Blood Loss in Spinal Deformity Surgery

Suk SI, Kim JH, Kim SS, Kim JH, Cho BC, Jung NY

PURPOSE: Complications are quite common in surgery to correct spinal deformities due to the long duration under anesthesia and massive blood loss. The aim of this study was to evaluate...
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Aprotinin Attenuates the Elevation of Pulmonary Vascular Resistance After Cardiopulmonary Bypass

Yun TJ, Rho JR

Pulmonary vascular resistance (PVR) is generally believed to be elevated after cardiopulmonary bypass (CPB) due to whole body inflammation. Aprotinin has an antiinflammatory action, and it was hypothesized that aprotinin...
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The Effect of Aprotinin for Reducing Blood Loss and Amount of Transfusion in Total Knee Arthroplasty

Choi YJ, Hwang JK, Ahn HS, Bae EJ, Kim CH, Kim E

  • KMID: 2182879
  • J Korean Knee Soc.
  • 2005 Dec;17(2):241-245.
PURPOSE: To evaluate the effect of Aprotinin in reducing postoperative blood loss and amount of transfusion in total knee arthroplasty. MATERIALS AND METHODS: In a prospective study, 100 patients undergoing bilateral...
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The Effect of Low Dose Aprotinin on Postreperfusion Fibrinolysis in Liver Transplantation

Park CS, Choi CH, Kim ES, Kim SY

BACKGROUND: The patients with end-staged liver failure are subjected to various and complex coagulopathies during liver transplantation. Particularly, fibrinolysis can occur preoperatively and is more prominent and aggravated right after...
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In Vitro and in Vivo Comparison of Antifibirinolytic Activity of Aprotinin and Tranexamic Acid Using a Thromboelastographic Method in Rabbits

Kim GS, Yang M, Cho HS, Cha SH, Kim JS, Park Q, Oh YS

BACKGROUND: Aprotinin and tranexamic acid are commonly used antifibrinolytics during liver transplantation, or cardiac surgery. However, it is not clear which drug is more effective to ameliorate the fibrinolysis. The...
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Acute Renal Failure after Operation Associated with Aprotinin: Report of 3 cases

Kim SC, Eom HS, Ok SY, Kim SI

Aprotinin is a serine protease inhibitor and a powerful antifibrinolytic agent, derived from the inhibition of plasmin and kallikrein. Therefore, it is widely used in cardiopulmonary bypass surgery or major...
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Effects of Aprotinin during Off-Pump Coronary Artery Bypass Grafting in Patients on Hemostasis Taking Aspirin

Kim TW, Ju YH, Cho HW, Lee SK, Kim YM, Moon HS

BACKGROUND: Patients with ischemic heart disease are frequently maintained on a regimen of aspirin because of its ability to reduce variable thrombotic complications. However, aspirin has been recognized as a...
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Effects of Cardiopulmonary Bypass and Aprotinin on Renal Function in Patients Undergoing Coronary Artery Bypass Grafting

Choi HS, Lee SK, Kim YM, Choi H, Moon HS

BACKGROUND: Perioperative renal dysfunction is a significant complication of coronary artery bypass grafting (CABG), and is associated with major increases in morbidity, mortality, and cost. The risk factors noted in...
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A Study of Preservation of Spinal Cord in Spinal Cord Ischemia of the Rabbit Comparison of Aprotinin and Pentoxifylline

Lee SY, Lee KR

  • KMID: 1941178
  • J Korean Soc Vasc Surg.
  • 2002 Apr;18(1):29-38.
PURPOSE: The complications of ischemic spinal cord injury on the descending and thoracoabdominal aorta remain a problem in spite of surgery and anesthesia advance. The protective effects of aprotinin and...
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Effects of Aprotinin on Acute Lung Injury by Endotoxin in Rabbits

Sim JY, Choi IC, Choi SK, Cho IH, Ko H

BACKGROUND: Aprotinin, a serine protease inhibitor, has an anti-inflammatory and hemostatic effect and has been used to reduce perioperative blood loss and lung injury after cardiopulmonary bypass in cardiac surgery....
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The Influence of High- and Low-Dose Aprotinin on Thromboelastography in Coronary Artery Bypass Grafting Surgery

Han JS, Jung SM, Lee SY, Yoo ES, Suh CK, Min SK

BACKGROUND: The protease inhibitor aprotinin reduces blood loss and homologous blood usage after a cardiac operation. The aim of the present study was to investigate the effect of low- and...
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Effect of Aprotinin on Changes in Plasma Thromboxane B2 and Endothelin-1 Concentratin after Extracorporeal Circulation

Lim C, Yun TC, Kim YS, Kim SH, Lee JD, Rho JR, Song MK

  • KMID: 1581859
  • Korean J Thorac Cardiovasc Surg.
  • 2000 Mar;33(3):221-229.
BACKGROUND: Thromboxane A2 and endothelin-1 are the potent vasoconstrictors affecting pulmonary pathophysiology in response to whole body inflammatin following CPB. Aprotinin, as an antiiflammatory agent, may decrease the release of such vasoactive...
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Intraoperative Anaphylactoid Reaction Due to Aprotinin during Pediatric Open Heart Surgery

Sim JY, Park JY, Kweon EH, Choi IC

Aprotinin is a serine protease inhibitor that improves the hemostatic function and modulates the anti-inflammatory responses. Recently, aprotinin has been widely used in various surgical procedures including open heart...
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