J Korean Acad Rehabil Med.  2002 Jun;26(3):243-248.

Severity of Disability and Serum Lipid Level according to the Genotype of Apolipoprotein E in Patients with Brain Injury

• Kim YH
• Kim KM
• Park SH
• Kim DS

Abstract

OBJECTIVE
This study was to investigate the relationship between genotype of Apolipoprotein E (Apo E) and severity of disability after brain injury as well as serum lipid profile. METHOD: One hundred thirty-five brain injured patients (mean age 54.6 16.7 years, 90 male and 45 female) were enrolled. There were 34 patients with ischemic Stroke, 61 hemorrhagic stroke, and 40 traumatic brain injury. Apo E genotype was determined by polymerase chain reaction and polyacrylamide gel electrophoresis. The serum concentra tions of total cholesterol, triglyceride, and HDL-cholesterol were measured. The outcome of brain injury was assessed by functional independence measure (FIM) scores.
RESULTS
Most frequent Apo E genotype was E 3/3 (72%). In hemorrhagic stroke patients with Epsilon4 allele, FIM score at admission was significantly lower than that of the patients without Epsilon4 allele (p<0.05). In traumatic brain injury patients with Epsilon4 allele, FIM score change was significantly smaller than that of patients without Epsilon4 allele (p<0.05). The level of total serum cholesterol was lower in the ischemic stroke patients who have Epsilon2 allele in comparison with the patients without that allele.
CONCLUSION
The presence of Epsilon4 allele is considered to have relationship with the severity of disability and functional outcome in the patients with brain injury.

Keyword

Apolipoprotein E genotype; Brain injury; FIM; Cholesterol

MeSH Terms

Alleles
Apolipoproteins E
Apolipoproteins*
Brain Injuries*
Brain*
Cholesterol
Electrophoresis, Polyacrylamide Gel
Genotype*
Humans
Male
Polymerase Chain Reaction
Stroke
Triglycerides
Apolipoproteins
Apolipoproteins E
Cholesterol