J Asthma Allergy Clin Immunol.
2001 Oct;21(5):940-947.
Inhalation effect of 1,1-dichloro-1-fluoroethane (HCFC-141b) on the respiratory system
- Affiliations
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- 1Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
- 2Institute of Allergy, Yonsei University College of Medicine, Seoul, Korea.
- 3Department of Pathology, Yonsei University College of Medicine, Seoul, Korea.
- 4Industrial Chemicals Research Center, Daejeon, Korea.
- 5Industrial Safety and Health Research Institute, Daejeon, Korea.
Abstract
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BACKGROUND: 1,1-dichloro-1-fluoroethane (HCFC-141b) has been known to be relatively safe except irritation of the skin and upper airway, and pulmonary disease directly associated with HCFC-141b exposure has not been reported yet.
OBJECTIVE
We report a highly suspicious case of HCFC-141b-related occupational asthma, which was assessed by workplace challenge, but not confirmed by specific inhalation test. We also performed animal experiment to evaluate whether long-term exposure to HCFC-141b could cause inflammation of the airway and parenchymal lung tissue. METHOD: Forty Sprague-Dawley rats were divided into 4 groups. HCFC-141b exposure for each group was carried out under the condition of 6 hours a day, 5 days a week for 13 weeks by inhalation with different concentration of HCFC-141b; Group A-control: Group B-low concentration, 1500 ppm: Group C-moderate concentration, 3000 ppm: and Group D-high concentration, 6000 ppm. Bronchoalveolar lavage (BAL) and histopathological examination of lung tissue was undertaken after HCFC-141b exposure.
RESULTS
HCFC-141b did not induce any abnormal change in the clinical and behavioral signs during and at the termination of the inhalation exposure. Compared with control rat, significantly abnormal findings in the microscopic examination of BAL and tissue preparations was not noted in HCFC-141b exposed rats.
CONCLUSION
We report a suspicious case of occupational asthma due to HCFC-141b exposure. Animal experiment, however, revealed that HCFC-141b has no toxic or side effect on the respiratory system regardless of its concentration.
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