J Korean Cancer Assoc.  1998 Feb;30(1):1-11.

Expression of p53 and MHC Class I According to HPV Infection in Laryngeal Squamous Cell Carcinomas

• Hwang CS
• Kim H
• Kim MK

Abstract

PURPOSE
We evaluated the HPV type 16, 18 infection and p53 expression and MHC class Iantigen expression, and analyzed he relationship between HPV infection and p53 expression and MHC class I expression in laryngeal squamous cell carcinomas.
MATERIALS AND METHODS
Thirty-nine cases of laryngeal squamous cell carcinomas and ten cases of laryngeal nodules were analyzed for detection of HPV DNA by in situ hybridization and the detection of p53 and MHC class I antigen by immunohistochemical technique.
RESULTS
HPV DNA was detected in 10(26%), and p53 expression was detected in 19(49%) out of 39 cases in laryngeal squamous cell carcinomas. HPV positive cases showed 50% of p53 expression whereas HPV negative cases showed 48% expression. MHC class I down-regulation (heterogenous and negative expression) in HPV positive lesions was higher than HPV negative lesions, but there was no statistically significance. The expression of MHC class I was related to cellular differentiation regardless of T-stage and nodal involvement.
CONCLUSION
There was no reiationship between HPV infection and p53 expression and MHC class I expression in laryngeal squamous cell carcinomas. Also these results suggest that MHC class I expression can make it possible to presume indirectly the malignant potentiality of the tumor.

Keyword

Human papillomavirus; p53; MHC class I; Laryngeal carcinoma

MeSH Terms

Carcinoma, Squamous Cell*
DNA
Down-Regulation
In Situ Hybridization
DNA