Patterns of the First Failure after Curative Resection of Gastric Cancer in Korean Female Patients

Kim, Hark Kyun; Ryu, Min Hee; Bang, Soo Mi; Yoo, Keun Young; Heo, Dae Seog; Bang, Yung Jue; Kim, Noe Kyeong

Abstract

PURPOSE: The major aim of this study is to evaluate the patterns of recurrence of the stomach cancer after curative resection.
MATERIALS AND METHODS
Patterns of the fimt failure and survival after relapse of 136 female gastric cancer patients who had received curative resection were evaluated. Factors influencing survival after relapse were analyzed using Cox proportional hazard model.
RESULTS
Peritoneal relapse was the most common pattern of the first failure, with 3-year estimate of overall peritoneal relapse being 13.0%. The 3-year estimates of overall local- regional relapse, liver metastasis, and extraabdominal relapse were 11.2%, 4.8%, and 3.8%, respectively. Patients younger than 45 years developed peritoneal relapse at a significantly higher rate than patients aged 45-65 years (p 0.037). The most significant factor affecting the survival of relapsed patients was whether resection was performed for recurrent disease without remaining gross residual disease. Patterns of relapse did not significantly affect survival, but patients whose recurrences were limited to local-regional area tended to survive longer than those with extraaMominal component (p=0.067).
CONCLUSION
Peritoneal relapse was the most common pattem and significantly associated with younger age after curative resection af gastric cancer of Korean female patients.