Intest Res.  2015 Jul;13(3):287-290. 10.5217/ir.2015.13.3.287.

Familial Mediterranean Fever With Complete Symptomatic Remission During Pregnancy

• Kim KT
• Jang HJ
• Lee JE
• Kim MK
• Yoo JJ
• Lee GY
• Kae SH
• Lee J

• KMID: 2174490
• DOI: http://doi.org/10.5217/ir.2015.13.3.287

Abstract

Familial Mediterranean fever (FMF) is an inherited autosomal recessive disorder, ethnically restricted and commonly found among populations surrounding the Mediterranean Sea. FMF is the most prevalent autoinflammatory disease; is characterized by recurrent, self-limited episodes of fever with serositis; and is caused by Mediterranean fever gene (MEFV) mutations on chromosome 16. We describe a case of adult-onset FMF with complete symptomatic remission during pregnancy, without the use of colchicine. A 25-year-old woman had presented with periodic fever, abdominal pain, and vomiting since she was 21. Her abdominal computed tomography scan showed intestinal nonrotation. She underwent exploratory laparotomy and appendectomy for her symptoms 1 year prior. She had a symptom-free pregnancy period, but abdominal pain and fever recurred after delivery. Mutation analysis of the MEFV gene revealed two point mutations (p.Leu110Pro and p.Glu148Gln). We report an adult female patient with FMF in Korea with complete symptomatic remission during pregnancy.

Keyword

Familial Mediterranean fever; Periodic fever syndrome; MEFV gene; Pregnancy

MeSH Terms

Abdominal Pain
Adult
Appendectomy
Chromosomes, Human, Pair 16
Colchicine
Familial Mediterranean Fever*
Female
Fever
Humans
Korea
Laparotomy
Mediterranean Sea
Point Mutation
Pregnancy*
Serositis
Vomiting
Colchicine

Figure

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  Fig. 1 Findings of abdominal CT and small bowel follow-through. Abdominal CT (A) and small bowel follow-through (B) showed nonrotation of the intestine, with the small intestine located to the right of the midline and the colon to the left of the midline.

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