Diabetes Metab J.  2013 Aug;37(4):252-261. 10.4093/dmj.2013.37.4.252.

Serum Adiponectin and Type 2 Diabetes: A 6-Year Follow-Up Cohort Study

• Jee SH
• Ahn CW
• Park JS
• Park CG
• Kim HS
• Lee SH
• Park S
• Lee M
• Lee CB
• Park HS
• Kimm H
• Choi SH
• Sung J
• Oh S
• Joung H
• Kim SR
• Youn HJ
• Kim SM
• Lee HS
• Mok Y
• Choi E
• Yun YD
• Baek SJ
• Jo J
• Huh KB

• KMID: 2174266
• DOI: http://doi.org/10.4093/dmj.2013.37.4.252

Abstract

BACKGROUND
Studies on factors which may predict the risk of diabetes are scarce. This prospective cohort study was conducted to determine the association between adiponectin and type 2 diabetes among Korean men and women.
METHODS
A total of 42,845 participants who visited one of seven health examination centers located in Seoul and Gyeonggi province, Republic of Korea between 2004 and 2008 were included in this study. The incidence rates of diabetes were determined through December 2011. To evaluate the effects of adiponectin on type 2 diabetes, the Cox proportional hazard model was used.
RESULTS
Of the 40,005 participants, 959 developed type 2 diabetes during a 6-year follow-up. After the adjustment for age, body mass index (BMI), and waist circumference, the risks for type 2 diabetes in participants with normoglycemia had a 1.70-fold (95% confidence interval [CI], 1.21 to 2.38) increase in men and a 1.83-fold (95% CI, 1.17 to 2.86) increase in women with the lowest tertile of adiponectin when compared to the highest tertile of adiponectin. For participants with impaired fasting glucose (IFG), the risk for type 2 diabetes had a 1.46-fold (95% CI, 1.17 to 1.83) increase in men and a 2.52-fold (95% CI, 1.57 to 4.06) increase in women with the lowest tertile of adiponectin. Except for female participants with normoglycemia, all the risks remained significant after the adjustment for fasting glucose and other confounding variables. Surprisingly, BMI and waist circumference were not predictors of type 2 diabetes in men or women with IFG after adjustment for fasting glucose and other confounders.
CONCLUSION
A strong association between adiponectin and diabetes was observed. The use of adiponectin as a predictor of type 2 diabetes is considered to be useful.

Keyword

Adiponectin; Cohort studies; Diabetes mellitus; Impaired fasting glucose

MeSH Terms

Adiponectin
Body Mass Index
Cohort Studies
Confounding Factors (Epidemiology)
Diabetes Mellitus
Fasting
Female
Follow-Up Studies
Glucose
Humans
Incidence
Male
Proportional Hazards Models
Prospective Studies
Republic of Korea
Waist Circumference
Adiponectin
Glucose

Figure

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  Fig. 1 Flow chart describing study population.

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  Fig. 2 The Kaplan-Meier survival curve demonstrating the association between adiponectin and type 2 diabetes among participants with normoglycemia during a 6-year follow-up (A) men, (B) women, (C) all subjects; adiponectin levels: men, (T1) high, ≥7.24, (T2) middle, 4.61-7.23, (T3) low, <4.61 µg/mL; women, (T1) high, ≥11.84, (T2) middle, 7.44-11.83, (T3) low, <7.44 µg/mL.

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  Fig. 3 The Kaplan-Meier survival curve demonstrating the association between adiponectin and type 2 diabetes among participants with impaired fasting glucose during a 6-year follow-up (A) men, (B) women, (C) all subjects; adiponectin levels: men, (T1) high, ≥6.24, (T2) middle, 3.91-6.23, (T3) low, <3.91 µg/mL; women, (T1) high, ≥9.42, (T2) middle, 5.99-9.41, (T3) low, <5.99 µg/mL.

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