J Korean Diabetes.  2015 Dec;16(4):252-259. 10.4093/jkd.2015.16.4.252.

Clinical Application of Glucagon-Like Peptide-1 Receptor Agonists

• Min SH
• Cho YM

• KMID: 2173851
• DOI: http://doi.org/10.4093/jkd.2015.16.4.252

Abstract

Glucagon-like peptide 1 (GLP-1) is an incretin hormone that is released from enteroendocrine L-cells upon nutrient absorption; it stimulates glucose-dependent insulin secretion from pancreatic betacells. GLP-1 has pleiotropic effects including deceleration of gastric emptying, decreased appetite, and increased satiety. Treatment with GLP-1 receptor agonists (GLP-1RAs) improves glycemic control in patients with type 2 diabetes without increasing the risk of hypoglycemia or weight gain. Current GLP-1RAs can be classified by their structure (exendin-4-based or human GLP-1-based), duration of action, and molecular size. Different GLP-1RAs exhibit different pharmacokinetics and pharmacodynamics. Herein we review the characteristics of available GLP-1RAs and discuss current issues such as insulin combination therapy and anti-obesity effects.

Keyword

Glucagon-like peptide 1; Obesity; Type 2 diabetes mellitus

MeSH Terms

Absorption
Appetite
Deceleration
Diabetes Mellitus, Type 2
Gastric Emptying
Glucagon-Like Peptide 1*
Humans
Hypoglycemia
Incretins
Insulin
Obesity
Pharmacokinetics
Weight Gain
Glucagon-Like Peptide-1 Receptor
Glucagon-Like Peptide 1
Incretins
Insulin

Reference

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