Endocrinol Metab.  2017 Mar;32(1):1-5. 10.3803/EnM.2017.32.1.1.

New Potential Targets of Glucagon-Like Peptide 1 Receptor Agonists in Pancreatic β-Cells and Hepatocytes

• Lee WY

• KMID: 2413278
• DOI: http://doi.org/10.3803/EnM.2017.32.1.1

Abstract

It is well known that both insulin resistance and decreased insulin secretory capacity are important factors in the pathogenesis of type 2 diabetes mellitus (T2DM). In addition to genetic factors, obesity and lipotoxicity can increase the risk of T2DM. Glucagon-like peptide 1 (GLP-1) receptor agonists are novel antidiabetic drugs with multiple effects. They can stimulate glucose-dependent insulin secretion, inhibit postprandial glucagon release, delay gastric emptying, and induce pancreatic β-cell proliferation. They can also reduce the weight of patients with T2DM and relieve lipotoxicity at the cellular level. Many intracellular targets of GLP-1 have been found, but more remain to be identified. Elucidating these targets could be a basis for developing new potential drugs. My colleagues and I have investigated new targets of GLP-1, with a particular focus on pancreatic β-cell lines and hepatic cell lines. Herein, I summarize the recent work from my laboratory, with profound gratitude for receiving the prestigious 2016 Namgok Award.

Keyword

Glucagon-like peptide-1 receptor; Diabetes mellitus; Insulin; Glucagon

MeSH Terms

Awards and Prizes
Diabetes Mellitus
Diabetes Mellitus, Type 2
Gastric Emptying
Glucagon
Glucagon-Like Peptide 1*
Glucagon-Like Peptide-1 Receptor
Hepatocytes*
Humans
Hypoglycemic Agents
Insulin
Insulin Resistance
Obesity
Glucagon
Glucagon-Like Peptide 1
Glucagon-Like Peptide-1 Receptor
Hypoglycemic Agents
Insulin

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