Chonnam Med J.  2005 Apr;41(1):97-101.

Therapeutic Effect of Cyclosporin A Eyedrops in Refractory Keratomycosis

• Yoon KC
• Heo H
• Park SW
• Park YG

Abstract

The efficacy and tolerance of cyclosporin A eyedrops were evaluated in refractory keratomycosis. Ten patients (10 eyes) with corneal fungal ulcer that had persisted despite topical and systemic antifungal medications were treated with 0.5% cyclosporin A eyedrops 4~6 times a day in addition to conventional therapy. The organism was identified by culture with corneal scraping or corneal biopsy. We investigated the duration and type of conventional therapy, the physical findings before and after cyclosporin A eyedrops therapy, and the results of the therapy. The mean age was 65.7+/-14.7 years, and the mean follow-up duration was 6.3+/-3.9 months. The mean time of conventional treatment was 1.6+/-0.7 months. The causative organisms were Fusarium spp. (5 eyes), Aspergillus spp. (3 eyes), and Candida spp. (2 eyes). The physical findings before cyclosporin A eyedrops therapy were persistent corneal inflammation and ulcer. All of the 10 eyes were healed requiring mean healing time of 1.1+/-0.5 months. We recommend the use of cyclosporin A eyedrops for the refractory keratomycosis as an adjuvant to antifungal agent.

Keyword

Eyedrops; Cycolsporin; Fungus; Corneal ulcer

MeSH Terms

Aspergillus
Biopsy
Candida
Corneal Ulcer
Cyclosporine*
Follow-Up Studies
Fungi
Fusarium
Humans
Inflammation
Ophthalmic Solutions*
Ulcer
Cyclosporine
Ophthalmic Solutions