Dement Neurocogn Disord.  2012 Mar;11(1):25-28. 10.12779/dnd.2012.11.1.25.

Neuro-Behcet's Disease Presented with Progressive Disinhibition

• Yi SE
• Park HK
• Lim TS
• Choi JY
• Hong YH
• Moon SY

• KMID: 2172263
• DOI: http://doi.org/10.12779/dnd.2012.11.1.25

Abstract

We report a man who presented with progressive disinhibition and through clinicoradiologic correlation using magnetic resonance imaging (MRI), aim to investigate the pathomechanism of disinhibition in neuro-Behcet's disease (NBD). A 46-year-old man presented with progressive disinhibition and apathy for 4 months. One month after his visit, additionally, he developed left partial third nerve palsy. His brain MRI showed lesions in the ventral caudate nucleus as well as left midbrain and thalamus. Taking his recurrent oral ulcers, uveitis, and erythema nodosum into consideration, he was diagnosed with NBD. We found that progressive disinhibition could be one of presenting symptoms in BD and might be associated with the caudate nucleus. This finding suggests that involvement of the basal ganglia in BD prior to the involvement of the brainstem could result in unique clinical features such as behavioral changes without extrapyramidal signs.

Keyword

Disinhibition; Neuro-Behcet's disease; Caudate nuclei

MeSH Terms

Apathy
Basal Ganglia
Brain
Brain Stem
Caudate Nucleus
Erythema Nodosum
Humans
Magnetic Resonance Imaging
Mesencephalon
Middle Aged
Oculomotor Nerve Diseases
Oral Ulcer
Thalamus
Uveitis

Figure

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  Fig. 1 Brain MRIs of this patient. (A) His brain MRI showed a lesion in the right ventral caudate nucleus with a small lesion in the left internal capsule. (B) His second MRI showed new lesions in the left midbrain, left internal capsule, and left thalamus with contrast enhancement.

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