Ann Dermatol.  2009 Feb;21(1):98-101. 10.5021/ad.2009.21.1.98.

A Case of Varicella Combined with Hand-foot-mouth Disease in a Healthy Child

• Na SY
• Son YM
• Lee HY
• Baek JO
• Roh JY
• Lee JR

• KMID: 2172080
• DOI: http://doi.org/10.5021/ad.2009.21.1.98

Abstract

We report here on an 11-year-old child with a pustulovesicular eruption on her whole body, including her palms, soles and oral mucosa, and this was accompanied with fever. A serologic test was positive for IgM varicella zoster antibody and coxsackievirus A16 antibody. The histopathologic examination from the palm revealed intraepidermal pustules that showed neither inclusion bodies nor multinucleated giant cells. We made the final diagnosis, according to the serologic tests and histopathologic findings, as varicella combined with hand-foot-mouth disease caused by coxsackievirus A16 in a previously healthy child

Keyword

Hand-foot-mouth disease; Varicella

MeSH Terms

Chickenpox
Child
Fever
Giant Cells
Herpes Zoster
Humans
Immunoglobulin M
Inclusion Bodies
Mouth Mucosa
Serologic Tests
Immunoglobulin M

Figure

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  Fig. 1 Erythematous pruritic vesicles, pustules and crusts on the whole body, including the face.

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  Fig. 2 Tender monomorphous pustules surrounded by an erythematous halo on the palms and soles.

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  Fig. 3 Painful erosion covered by whitish membrane (2 mm in diameter) on the hard palate of the oral mucosa.

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  Fig. 4 Intraepidermal pustule with reticular degeneration showing neither inclusion bodies nor multinucleated giant cells (A: H&E, ×40, B: H&E, ×200).

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