Ann Dermatol.  2014 Apr;26(2):150-155. 10.5021/ad.2014.26.2.150.

Effect of Emollients Containing Vegetable-Derived Lactobacillus in the Treatment of Atopic Dermatitis Symptoms: Split-Body Clinical Trial

• Park SB
• Im M
• Lee Y
• Lee JH
• Lim J
• Park YH
• Seo YJ

• KMID: 2171648
• DOI: http://doi.org/10.5021/ad.2014.26.2.150

Abstract

BACKGROUND
Atopic dermatitis (AD) patients suffer from xerosis. Proper skin care, including the use of emollients, may help improve xerosis and minimize disease exacerbation. Lactobacillus sakei probio 65, isolated from the Korean vegetable-based product kimchi, can decrease interleukin 4 and immunoglobulin E levels and inhibit Staphylococcus aureus. Moreover, it has reportedly shown positive dermatological effects in both animal and clinical studies.
OBJECTIVE
To compare the effects of an emollient that contains Lactobacillus (treated) with a normal emollient (control) on AD.
METHODS
This double-blind, randomized, split-body clinical trial involved 28 patients with AD. The patients applied the Lactobacillus-containing emollient on one side of their body and the control emollient on the other side twice daily for 4 weeks. Trans-epidermal water loss (TEWL) and skin capacitance were evaluated and investigator global assessment and the visual analogue scale (VAS) were administered on weeks 0, 1, 2, and 4.
RESULTS
The treated sides had significantly lower TEWL and VAS values and significantly higher skin capacitance values over time than the control sides.
CONCLUSION
Topical application of Lactobacillus-containing emollients may improve the skin permeability of patients with AD.

Keyword

Atopic dermatitis; Emollients; Lactobacillus

MeSH Terms

Animals
Dermatitis, Atopic*
Disease Progression
Emollients*
Humans
Immunoglobulin E
Immunoglobulins
Interleukin-4
Lactobacillus*
Permeability
Research Personnel
Skin
Skin Care
Staphylococcus aureus
Water Loss, Insensible
Emollients
Immunoglobulin E
Immunoglobulins
Interleukin-4
Water Loss, Insensible

Figure

• 

  Fig. 1 Three groups showed no responses in eye stimulation test (top: PBS, middle: Lactobacillus sakei probio 65 extract containing emollient, bottom: L. sakei probio 65 extract) (A) and skin stimulation test (left: PBS, middle: L. sakei probio 65 extract, right: L. sakei probio 65 extract containing emollient) (B). PBS: phosphate buffer saline.

• 

  Fig. 2 Effect of emollients containing Lactobacillus in atopic dermatitis patients at basline (A) and after 4 weeks (B).

• 

  Fig. 3 Effect of emollients containing Lactobacillus assessed from IGA (A), VAS of pruritus (B), TEWL scores (C), and skin capacitance values of control and treatment sides (D). IGA: investigator's global assessment, VAS: visual analogue scale, TEWL: trans-epidermal water loss.

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