Int J Thyroidol.  2015 Nov;8(2):147-152. 10.11106/ijt.2015.8.2.147.

Understanding of Cancer Cell Metabolism and Thyroid Cancer

• Kim WG
• Kim WB

• KMID: 2171222
• DOI: http://doi.org/10.11106/ijt.2015.8.2.147

Abstract

Metabolic reprogramming of cancer cell is one of essential hallmarks of cancer. Otto Warburg first demonstrated that cancer cells utilized more glucose and enhanced glycolytic pathway in the presence of oxygen in 1926. Scientific observations of basic and clinical research in several decades supported that cancer-specific metabolism can be an emerging target for treatment of cancer. Metabolic reprogramming is regulated by both oncogenic signaling and tumor suppressor genes associated with critical signaling pathways in metabolism. These changes provided energy, substrates for cell growth and proliferation, favoring microenvironment, and important for redox balancing for cancer cells. Recent advance of several tools for evaluation comprehensive metabolic profiles of cancer cells provided us to identification of metabolic Achilles' heel of cancers including thyroid cancer. This approach can be a useful strategy for advance in treatment of cancer patients.

Keyword

Cancer; Metabolism; Metabolome; Warburg effect

MeSH Terms

Genes, Tumor Suppressor
Glucose
Heel
Humans
Metabolism*
Metabolome
Oxidation-Reduction
Oxygen
Thyroid Gland*
Thyroid Neoplasms*
Glucose
Oxygen

Figure

• 

  Fig. 1. Summary of changes in metabolic characteristics of cancer cells. 3PG: 3-phos-phoglycerate, α KG: alpha- ketoglutarate, AcCoA: Acetyl coenzyme A, FA: fatty acids, G6P: glucose-6-phosphate, Gln: glutamate, Glu: gluta-mine, PPP: pentose phos-phate pathway. Bold arrow indicates increase of meta-bolic pathways in cancers.

Reference

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