Clin Psychopharmacol Neurosci.
2013 Dec;11(3):165-167.
Blonanserin-induced Mood Alteration in Schizophrenia and Schizoaffective Disorder: Two Cases
- Affiliations
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- 1Department of Psychiatry, Hanyang University Medical Center, Hanyang University School of Medicine, Seoul, Korea. dkim9289@hanyang.ac.kr
Abstract
- We report two outpatients, one with schizophrenia and one with schizoaffective disorder, who developed manic or hypomanic episodes following the initiation of blonanserin during the course of treatment. Blonanserin is a novel antipsychotic that acts as a 5-HT and D2 receptor antagonist. Both patients developed hypomanic episodes within 2 weeks of receiving a small dose (6-8 mg) of blonanserin, and one patient later developed full-blown mania; both episodes ended within 1 month of discontinuing blonanserin. The mood alteration observed in these cases suggests a possible antidepressant effect of blonanserin; thus, clinicians should monitor mood changes when administering this antipsychotic.
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