Ewha Med J.  2004 Mar;27(1):63-69. 10.12771/emj.2004.27.1.63.

A Case of Type II Membranousproliferative Glomerulonephritis with Hump (Dense Deposit Disease)

• Oh HJ
• Yu MA
• Lee YS
• Kim MY
• Kim SJ
• Kang DH
• Yun GI
• Choi KB
• Sung SH

• KMID: 2171142
• DOI: http://doi.org/10.12771/emj.2004.27.1.63

Abstract

Dense deposit disease (DDD), known as type II MPGN, is an uncommon form of glomerulonephritis. It is an acquired primary glomerular disease, characterised by electron microscopic evidence of a continous, dense membrane deposition replacing the lamina densa. There is associated alternative pathway complement activation and a C3 nephritic factor maybe present. Patients with dense deposit disease tend to be young at clincal onset and more commonly have persistent nephrotic syndrome, gross hematuria, and acute nephritis episode and persistent depression of the serum complement level. The prognosis of dense deposit disease is worse than that of type I MPGN. We experienced a patient with dense deposit disease that presenting persistent nephrotic syndrome, gross hematuria and having subepithelial hump. It is a first report of dense deposit disease having subepithelial hump in Korea, therefore we report this case with the review of relevant literatures.

Keyword

Dense deposit disease; Type II MPGN; Subepithelial hump

MeSH Terms

Complement Activation
Complement C3 Nephritic Factor
Complement System Proteins
Depression
Glomerulonephritis*
Glomerulonephritis, Membranoproliferative
Hematuria
Humans
Korea
Membranes
Nephritis
Nephrotic Syndrome
Prognosis
Complement C3 Nephritic Factor
Complement System Proteins