Child Kidney Dis.  2019 Oct;23(2):93-99. 10.3339/jkspn.2019.23.2.93.

Pathology of C3 Glomerulopathy

• Shin SJ
• Seong Y
• Lim BJ

• KMID: 2464933
• DOI: http://doi.org/10.3339/jkspn.2019.23.2.93

Abstract

C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed by immunofluorescence microscopy. Dense deposit disease (DDD) and C3 glomerulonephritis (C3GN) are subclasses of C3 glomerulopathy that are distinguishable by electron microscopy. Highly electron-dense transformation of glomerular basement membrane is characteristic of DDD. C3GN should be differentiated from post-infectious glomerulonephritis and other immune complex-mediated glomerulonephritides showing C3 deposits.

Keyword

C3 glomerulopathy; C3 glomerulonephritis; Membranoproliferative glomerulonephritis; Dense deposit disease; Alternative complement pathway

MeSH Terms

Complement Activation
Complement Pathway, Alternative
Dichlorodiphenyldichloroethane
Glomerular Basement Membrane
Glomerulonephritis
Glomerulonephritis, Membranoproliferative
Microscopy, Electron
Microscopy, Fluorescence
Pathology*
Prevalence
Dichlorodiphenyldichloroethane