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Electroretinography Changes in Feline Model of Iodoacetic Acid-induced Retinal Degeneration

Kim C, Lee M, Lee SU, Lee SJ

PURPOSE: We explored changes in photoreceptor function and histology in an iodoacetic acid (IAA)-induced model of feline retinal degeneration. METHODS: From January to October 2014, we studied 11 adult felines (22...
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Pathology of C3 Glomerulopathy

Shin SJ, Seong Y, Lim BJ

C3 glomerulopathy is a renal disorder involving dysregulation of alternative pathway complement activation. In most instances, a membranoproliferative pattern of glomerular injury with a prevalence of C3 deposition is observed...
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Changes in the composition of artificial cariogenic biofilms over time

Oh C, Pandit S, Jeon JG

OBJECTIVES: The purpose of this study was to investigate changes in the composition of artificial cariogenic biofilms using a Streptococcus mutans biofilm model over a period of time. METHODS: We analyzed...
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Anti-malarial Drugs Reduce Vascular Smooth Muscle Cell Proliferation via Activation of AMPK and Inhibition of Smad3 Signaling

Lee H, Han JH, Kim S, Kim S, Cho DH, Woo CH

OBJECTIVE: The aim of this study was to investigate the effects of 2 anti-malarial drugs, chloroquine (CQ) and hydroxychloroquine (HCQ), on inhibition of vascular smooth muscle cell (VSMC) proliferation both...
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Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiR-186-5p/MAP4K3 Axis in Hepatocellular Carcinoma

Shan Y, Li P

PURPOSE: Long intergenic non-protein coding RNA 665 (LINC00665) plays a vital role in the development of cancer. Its function in hepatocellular carcinoma (HCC), however, remains largely unknown. MATERIALS AND METHODS: The...
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Recent trends in two-photon auto-fluorescence lifetime imaging (2P-FLIM) and its biomedical applications

Ranawat H, Pal S, Mazumder N

Two photon fluorescence microscopy and the numerous technical advances to it have served as valuable tools in biomedical research. The fluorophores (exogenous or endogenous) absorb light and emit lower energy...
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Differentiation Capacity of Monocyte-Derived Multipotential Cells on Nanocomposite Poly(e-caprolactone)-Based Thin Films

Koliakou I, Gounari E, Nerantzaki M, Pavlidou E, Bikiaris D, Kaloyianni M, Koliakos G

BACKGROUND: Lonocyte-derived multipotential cells (MOMCs) include progenitors capable of differentiation into multiple cell lineages and thus represent an ideal autologous transplantable cell source for regenerative medicine. In this study, we...
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An Enzymolysis-Assisted Agrobacterium tumefaciens-Mediated Transformation Method for the Yeast-Like Cells of Tremella fuciformis

Wang Y, Xu D, Sun X, Zheng L, Chen L, Ma A

Agrobacterium tumefaciens-mediated transformation (ATMT), as a simple and versatile method, achieves successful transformation in the yeast-like cells (YLCs) of Tremella fuciformis with lower efficiency. Establishment of a more efficient transformation...
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Effect of Sphingosine-1-Phosphate on Intracellular Free Ca2+ in Cat Esophageal Smooth Muscle Cells

Lee DK, Min YS, Yoo SS, Shim HS, Park SY, Sohn UD

A comprehensive collection of proteins senses local changes in intracellular Ca²⁺ concentrations ([Ca²⁺](i) and transduces these signals into responses to agonists. In the present study, we examined the effect of...
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A Novel Method to Study the Effects of Cyclosporine on Gingival Overgrowth in Children

Han K, Kim J

Previous studies to elucidate the etiology of cyclosporine(Cs)-induced gingival overgrowth in children have not completely excluded all factors that may cause differences among individuals. This study examined the effect of...
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Local Mesenchymal Stem Cell Therapy in Experimentally Induced Colitis in the Rat

de la Portilla F, Yuste Y, Pereira S, Olano C, Maestre MV, Padillo FJ

BACKGROUND: Multipotent mesenchymal stem cells (MSCs) have been used in inflammatory bowel diseases because of their immunomodulatory and regenerative properties. We investigated their local use in an experimental model of...
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Primary Glomerulonephritis with Unique C4d Deposition and Concurrent Non-infectious Intermediate Uveitis: a Case Report and Literature Review

Park JM, Lee H, Song S, Seong EY, Kwak IS, Park SW, Kim YK, Shin N, Sol MY

C4 glomerulopathy is a recently introduced entity that presents with bright C4d staining and minimal or absent immunoglobulin and C3 staining. We report a case of a 62-year-old man with...
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Combined Effects of Baicalein and Docetaxel on Apoptosis in 8505c Anaplastic Thyroid Cancer Cells via Downregulation of the ERK and Akt/mTOR Pathways

Park CH, Han SE, Nam-Goong , Kim YI, Kim ES

BACKGROUND: Anaplastic thyroid cancer (ATC) is one of the most lethal human malignancies. Docetaxel, a microtubule stabilizer, is a common chemotherapeutic agent used to treat various metastatic cancers. However, prolonged...
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Root canal irrigants influence the hydrophobicity and adherence of Staphylococcus epidermidis to root canal dentin: an in vitro study

Nagendrababu V, Sheriff Sultan O, Kannathasan S, Patel AS, Chitra E, Neelakantan P, Davamani F

OBJECTIVES: To determine the effect of root canal irrigants on the hydrophobicity and adherence of Staphylococcus epidermidis (S. epidermidis) to root canal dentin in vitro. MATERIALS AND METHODS: Root dentin blocks...
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Poloxamer 407 Hydrogels for Intravesical Instillation to Mouse Bladder: Gel-Forming Capacity and Retention Performance

Kim SH, Kim SR, Yoon HY, Chang IH, Whang YM, Cho MJ, Kim MJ, Kim SY, Lee SJ, Choi YW

PURPOSE: Poloxamer 407 (P407) thermo-sensitive hydrogel formulations were developed to enhance the retention time in the urinary bladder after intravesical instillation. MATERIALS AND METHODS: P407 hydrogels (P407Gels) containing 0.2 w/w% fluorescein...
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Adherence of Candida to complete denture surfaces in vitro: A comparison of conventional and CAD/CAM complete dentures

Al-Fouzan , Al-mejrad , Albarrag A

PURPOSE: The goal of this study was to compare the adhesion of Candida albicans to the surfaces of CAD/CAM and conventionally fabricated complete denture bases. MATERIALS AND METHODS: Twenty discs of...
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Epithelioid angiomyolipoma of the liver: a case report

Lee SY, Kim BH

Epithelioid angiomyolipoma (EAML) of liver is a rare neoplasm. Hepatic EAML is often misdiagnosed as other neoplasms such as hepatocellular carcinoma due to non-specific clinical and radiologic features. The morphologic...
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Hepatic perivascular epithelioid cell tumor (PEComa): a case report with a review of literatures

Son HJ, Kang DW, Kim JH, Han HY, Lee MK

Hepatic perivascular epithelioid cell tumors (PEComas) are very rare. We report a primary hepatic PEComa with a review of the literature. A 56-year-old women presented with a nodular mass detected...
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Chracterization of THP-1 Cell Death Induced by Porphyromonas gingivalis Infection

Song Y, Kim S, Park MH, Na HS, Chung J

BACKGROUND: Periodontitis is generally a chronic disorder characterized by the breakdown of tooth-supporting tissues. P. gingivalis, a Gram-negative anaerobic rod, is one of the major pathogens associated with periodontitis. Frequently,...
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Propofol protects against oxidative-stress-induced COS-7 cell apoptosis by inducing autophagy

Yoon JY, Baek CW, Kim EJ, Park BS, Yu SB, Yoon JU, Kim EN

BACKGROUND: In oxidative stress, reactive oxygen species (ROS) production contributes to cellular dysfunction and initiates the apoptotic cascade. Autophagy is considered the mechanism that decreases ROS concentration and oxidative damage....
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