Clin Psychopharmacol Neurosci.  2016 Feb;14(1):96-100. 10.9758/cpn.2016.14.1.96.

Paliperidone Palmitate-induced Urinary Incontinence: A Case Report

• Karslioglu EH
• Ozalp E
• Caykoylu A

• KMID: 2171007
• DOI: http://doi.org/10.9758/cpn.2016.14.1.96

Abstract

Urinary incontinence, although rarely reported, is one of the most important adverse effects of antipsychotic medication. It can be an embarrassing, distressing, and potentially treatment-limiting. Several antipsychotics, including both typical and atypical varieties, are known to induce urinary incontinence. Many antipsychotic drugs target the neural pathways controlling continence by binding to receptors of some neurotransmitters such as serotonin, dopamine, acetylcholine, and adrenaline. Pharmacological management of incontinence should be considered if there is a risk of cessation of the antipsychotic therapy or any decline in patients' compliance. Amitriptyline, desmopressin, ephedrine, and anticholinergics such as oxybutynin and trihexyphenidyl are the most frequently used agents to treat incontinence. We think that the frequency of incontinence is higher than reported in the literature, and that follow-up routines should include a form of standardized screening for all possible adverse effects, including incontinence, of any given antipsychotic. In this article, we report a case of urinary incontinence as an adverse effect of paliperidone palmitate use during maintenance therapy in a patient with schizophrenia.

Keyword

Antipsychotic agents; Schizophrenia; Paliperidone palmitate; Adverse effects; Urinary incontinence

MeSH Terms

Acetylcholine
Amitriptyline
Antipsychotic Agents
Cholinergic Antagonists
Compliance
Deamino Arginine Vasopressin
Dopamine
Ephedrine
Epinephrine
Follow-Up Studies
Humans
Mass Screening
Neural Pathways
Neurotransmitter Agents
Schizophrenia
Serotonin
Trihexyphenidyl
Urinary Incontinence*
Paliperidone Palmitate
Acetylcholine
Amitriptyline
Antipsychotic Agents
Cholinergic Antagonists
Deamino Arginine Vasopressin
Dopamine
Ephedrine
Epinephrine
Neurotransmitter Agents
Serotonin
Trihexyphenidyl