Ewha Med J.  1998 Sep;21(3):119-126. 10.12771/emj.1998.21.3.119.

Correlation between Lipoprotein(a) and Abdominal Aorta Thickness and Aortic and Mitral Valve Sclerosis

• Kim MS
• You KB
• Lee SW
• Lim YH
• Shin GJ
• Cho HK

• KMID: 2170944
• DOI: http://doi.org/10.12771/emj.1998.21.3.119

Abstract

BACKGROUND
An elevated serum lipoprotein(a) level is an independent risk factor for atherosclerotic diseases, and the lipoprotein(a) level is correlated to preclinical atherosclerosis. To evaluate the association between lipoprotein(a) and aortic selerosis, mitral sclerosis, and abdominal aorta thickness, we measured the aortic valve thickness, mitral valve thickness and abdominal aorta thickness. Also, we assessed the relationship between the aortic valve sclerosis, mitral valve sclerosis, abdominal aorta thickness and other coronary risk factors. METHOD: We measured serum lipoprotein(a) in 116 patients(52 men, 64 women) with mean age of 58.7+/-13.9 years. Aortic valve thickness was assessed by parasternal long and short axis two dimensional echocardiography, mitral valve thickness was measured by apical 4 chamber view. The abdominal aorta thickness was measured by the subcostal view. RESULT: The level of lipoprotein(a) was significantly correlated with the aortic valve thickness, but not with the miral valve thickness and the abdominal aorta thickness. lipoprotein(a) level was higher in smoking patients(p<0.05), and not related to other ariables such as blood pressure, age, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein. Coronary angiography was performed in 18 paitents, and there was a tendency of the coronary artery disease with high level of the lipoprotein(a)(p<0.005). There was no significant difference in the thickness of aortic valve in terms of sex, blood pressure, total cholesterol, high density lipoprotein, triglyceride or blodo sugar.
CONCLUSION
We conclude that increased serum levels of lipoprotein(a) are closely related to aortic valve sclerosis and may be a risk factor for coronary artery disease.

Keyword

Lipoprotein(a); Aortic sclerosis; Mitral sclerosis; Abdominal aorta thickness; Echocardiography

MeSH Terms

Aorta, Abdominal*
Aortic Valve
Atherosclerosis
Blood Pressure
Cholesterol
Coronary Angiography
Coronary Artery Disease
Echocardiography
Humans
Lipoprotein(a)*
Lipoproteins
Male
Mitral Valve*
Risk Factors
Sclerosis*
Smoke
Smoking
Triglycerides
Axis, Cervical Vertebra
Cholesterol
Lipoprotein(a)
Lipoproteins
Smoke