Infect Chemother.  2016 Mar;48(1):1-11. 10.3947/ic.2016.48.1.1.

Clinical Usefulness of Arbekacin

Affiliations
  • 1Department of Internal Medicine, Wonkwang University Medical School, Iksan, Korea.
  • 2Department of Internal Medicine, Chonbuk National University, Jeonju, Korea. lcsmd@jbnu.ac.kr
  • 3Research Institute of Clinical Medicine, Chonbuk National University, Jeonju, Korea.
  • 4Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Korea.

Abstract

Arbekacin is a broad-spectrum aminoglycoside used to treat methicillin-resistant Staphylococcus aureus (MRSA). Arbekacin has antibacterial activities against high-level gentamicin-resistant Enterococci, multidrug-resistant Pseudomonas aeruginosa, and Acinetobacter baumannii et al. Here, we reviewed in vitro data on arbekacin in Staphylococci and Gram-negative microorganisms. We also reviewed clinical studies for clinical efficacy and microbiologic efficacy data in patients with identified MRSA and suspected MRSA infections. The overall clinical efficacy ranged from 66.7% to 89.7%. The microbiologic efficacy rate ranged from 46.2% to 83%. In comparative studies between arbekacin and glycopeptides, arbekacin was similar to other glycopeptides with respect to clinical and microbiological efficacy rates. Combination trials with other antibiotics suggest that arbekacin will be a promising strategy to control Enterococcus spp. multi-drug resistant P. aeruginosa. The major adverse reaction was nephrotoxicity/hepatotoxicity, but patients recovered from most adverse reactions without any severe complications. Based on these results, arbekacin could be a good alternative to vancomycin/teicoplanin in MRSA treatment. Finally, therapeutic drug monitoring is recommended to maximize clinical efficacy and decrease nephrotoxicity.

Keyword

Arbekacin; Methicillin-resistant Staphylococcus aureus; Glycopeptides; Alternative; Antibiotics

MeSH Terms

Acinetobacter baumannii
Anti-Bacterial Agents
Drug Monitoring
Enterococcus
Glycopeptides
Humans
Methicillin-Resistant Staphylococcus aureus
Pseudomonas aeruginosa
Anti-Bacterial Agents
Glycopeptides
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