Infect Chemother.  2012 Jun;44(3):168-174. 10.3947/ic.2012.44.3.168.

Prognostic Factors of Community-acquired Bacteremic Patients with Severe sepsis: A Prospective, Observational Study

• Yoon YK
• Kim MJ
• Park DW
• Kwon SS
• Chun BC
• Cheong HJ
• Choi JY
• Choi HJ
• Choi YH
• Kim HY
• Eom JS
• Kim SI
• Song YG
• Peck KR
• Kim YS
• Kim JM
• Sohn JW
• Korean Sepsis Working Group

• KMID: 2170366
• DOI: http://doi.org/10.3947/ic.2012.44.3.168

Abstract

BACKGROUND
Characterization of clinical features of bacteremic severe sepsis acquired from the community has been inadequate; therefore, our goal in this study was to identify prognostic factors associated with outcome in patients with community-acquired bacteremic severe sepsis.
MATERIALS AND METHODS
Adult patients (> or =18 years) with community-acquired severe sepsis in whom pathogens were identified from blood cultures were included in the study. Data were collected prospectively from 12 teaching hospitals between May, 2005, and February, 2009. Data included demographic characteristics, co-morbid medical conditions, primary infection sites, sepsis severity, mortality, causative microorganisms, and the appropriateness of initial empirical antibiotic therapy.
RESULTS
During the study period, 1,152 patients were diagnosed with community-acquired severe sepsis and 422 patients were found to harbor pathogens in their blood. Among the 422 patients analyzed, 253 (60.0%) patients went into shock and 121 patients (28.7%) died during hospitalization. Risk factors, including respiratory tract infection (odds ratio [OR], 2.60; 95% confidence interval [CI], 1.11-6.09), number of organ dysfunctions (OR, 1.39; 95% CI, 1.13-1.71), and higher APACHE II scores (OR, 1.08; 95% CI, 1.03-1.13) showed an association with poor survival, whereas Escherichia coli as a pathogen (OR, 0.31; 95% CI, 0.16-0.64) showed an association with lower mortality.
CONCLUSIONS
In addition to severity of illness, the primary site of infection and causative microorganisms were also identified as important prognostic factors in patients with community-acquired bacteremic severe sepsis.

Keyword

Prognostic factors; Severe sepsis; Septic shock; Community-acquired infections; Bacteremia

MeSH Terms

Adult
APACHE
Bacteremia
Community-Acquired Infections
Escherichia coli
Hospitalization
Hospitals, Teaching
Humans
Prospective Studies
Respiratory Tract Infections
Risk Factors
Sepsis
Shock
Shock, Septic

Figure

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  Figure 1 Process used for selection of eligible patients with bacteremia from among those with severe community-acquired sepsis.

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