Infect Chemother.  2006 Jun;38(3):164-168.

Two Cases of Candida inconspicua Infection in Neutropenic Patients with Acute Leukemia

Affiliations
  • 1Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea. fire@catholic.ac.kr
  • 2Department of Clinical Pathology, College of Medicine, The Catholic University of Korea, Seoul, Korea.

Abstract

Non-albicans Candida species which are resistant to azole are emerging as important pathogens in patients with hematological malignancies who received antifungal prophylaxis. C. inconspicua is one of rare Candida spp. and resistant to fluconazole and deep infection due to C. inconspicua has not been reported in Korea so far. We reported here two cases of candidemia due to C. inconspicua in neutropenic patients with acute leukemia. C. inconspicua were presumed to be originated from gastrointestinal tract in both cases. The antifungal susceptibility test of C. inconspicua in case 1 showed resistance to fluconazole and itraconazole. Both cases were successfully treated by amphotericin B deoxycholate. Clinicians should keep in mind that non-albicans Candida species would be emerging pathogen in immunocompromised hosts and early recognition and appropriate use of antifungal agents is necessary.

Keyword

Candida inconspicua; Fungemia; Neutropenia

MeSH Terms

Amphotericin B
Antifungal Agents
Candida*
Candidemia
Danazol
Deoxycholic Acid
Fluconazole
Fungemia
Gastrointestinal Tract
Hematologic Neoplasms
Humans
Immunocompromised Host
Itraconazole
Korea
Leukemia*
Neutropenia
Amphotericin B
Antifungal Agents
Danazol
Deoxycholic Acid
Fluconazole
Itraconazole
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