Korean J Pediatr Hematol Oncol.  1997 Oct;4(2):363-369.

Disseminated Fusarial Infections in Two Children with Acute Leukemia

Abstract

Disseminated Fusarium infection has rarely been encountered in neutropenic cancer patients. The clinical features include fever, positive blood cultures, severe myalgias, disseminated ecthyma gangrenosum-like skin lesions, ocular symptoms and multi-organ-system involvement. The mortality rate reported so far exceeded 70% despite antifungal treatments. We report here the first two cases of disseminated fusarial infections in Korea. The first patient contracted pneumonia during severe neutropenic period following consolidation chemotherapy for acute myelogenous leukemia(AML). Fusarium oxyshrum was cultured from bronchoalveolar lavage fluid. The patient remains free of fungemia after successful antifungal treatment of high-dose amphotericin B and terbinafine. The second patient had relapsed AML and suffered from disseminated fusarial infection involving lungs with characteristic skin lesions. The patient succumbed to refractory leukemia and the fungal infection. A brief review of the literature ensues with the case report.

Keyword

Fusarium; Acute leukemia; Children; Amphotericin B; Terbinafine

MeSH Terms

Amphotericin B
Bronchoalveolar Lavage Fluid
Child*
Consolidation Chemotherapy
Ecthyma
Fever
Fungemia
Fusariosis
Fusarium
Humans
Korea
Leukemia*
Lung
Mortality
Myalgia
Pneumonia
Skin
Amphotericin B
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