Endocrinol Metab.  2011 Mar;26(1):62-66. 10.3803/EnM.2011.26.1.62.

Association of the Parathyroid Adenoma Volume and the Biochemical Parameters in Primary Hyperparathyroidism

Affiliations
  • 1Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. csshin@snu.ac.kr

Abstract

BACKGROUND
The objective of this study is to demonstrate the relationship between the volume of a parathyroid adenoma and the preoperative biochemical parameters in patients undergoing surgery for primary hyperparathyroidism.
METHODS
The medical records of 68 patients who underwent a parathyroidectomy for a single parathyroid adenoma were retrospectively reviewed. The volume of the adenoma was estimated using its measured size and a mathematical formula. The correlation between the volume of the parathyroid adenoma and the preoperative laboratory data was assessed.
RESULTS
There were no correlations between the estimated volume of the adenoma and the serum calcium, alkaline phosphatase and parathyroid hormone levels. However, the volume of the adenoma was associated with the preoperative level of serum phosphorus. After excluding 5 adenomas with cystic degeneration, a positive correlation was noted between the adenoma volume and the preoperative levels of alkaline phosphatase and parathyroid hormone.
CONCLUSION
The preoperative serum levels of calcium, alkaline phosphatase and parathyroid hormone are of limited use to predict the volume of the parathyroid adenoma in patients with a single parathyroid adenoma. We suggest that the absence of a correlation between the volume of the adenoma and the biochemical parameters can be attributed to the cystic degeneration of the adenomas.

Keyword

Hyperparathyroidism; Parathyroid adenoma; Parathyroidectomy

MeSH Terms

Adenoma
Alkaline Phosphatase
Calcium
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary
Medical Records
Parathyroid Hormone
Parathyroid Neoplasms
Parathyroidectomy
Phosphorus
Retrospective Studies
Alkaline Phosphatase
Calcium
Parathyroid Hormone
Phosphorus

Reference

1. Kebebew E, Hwang J, Reiff E, Duh QY, Clark OH. Predictors of single-gland vs multigland parathyroid disease in primary hyperparathyroidism: a simple and accurate scoring model. Arch Surg. 2006. 141:777–782.
2. Mariani G, Gulec SA, Rubello D, Boni G, Puccini M, Pelizzo MR, Manca G, Casara D, Sotti G, Erba P, Volterrani D, Giuliano AE. Preoperative localization and radioguided parathyroid surgery. J Nucl Med. 2003. 44:1443–1458.
3. Irvin GL 3rd. American Association of Endocrine Surgeons. Presidential address: chasin' hormones. Surgery. 1999. 126:993–997.
4. Irvin GL 3rd, Carneiro DM, Solorzano CC. Progress in the operative management of sporadic primary hyperparathyroidism over 34 years. Ann Surg. 2004. 239:704–708.
5. Dubost C, Bordier PJ, Ferry J, Gueris J. (The estimation of parathormone in primary hyperparathyroidism). Nouv Presse Med. 1978. 7:21–25.
6. Rutledge R, Stiegel M, Thomas CG Jr, Wild RE. The relation of serum calcium and immunoparathormone levels to parathyroid size and weight in primary hyperparathyroidism. Surgery. 1985. 98:1107–1112.
7. Zamboni WA, Folse R. Adenoma weight: a predictor of transient hypocalcemia after parathyroidectomy. Am J Surg. 1986. 152:611–615.
8. Saxe AW, Lincenberg S, Hamburger SW. Can the volume of abnormal parathyroid tissue be predicted by preoperative biochemical measurement? Surgery. 1987. 102:840–845.
9. Hedback G, Oden A, Tisell LE. Parathyroid adenoma weight and the risk of death after treatment for primary hyperparathyroidism. Surgery. 1995. 117:134–139.
10. Randhawa PS, Mace AD, Nouraei SA, Stearns MP. Primary hyperparathyroidism: do perioperative biochemical variables correlate with parathyroid adenoma weight or volume? Clin Otolaryngol. 2007. 32:179–184.
11. Saadeh G, Licata A, Esselstyn C, Gupta M. Relationship of parathyroid adenoma volume and biochemical function. Horm Res. 1989. 32:142–144.
12. Williams JG, Wheeler MH, Aston JP, Brown RC, Woodhead JS. The relationship between adenoma weight and intact (1-84) parathyroid hormone level in primary hyperparathyroidism. Am J Surg. 1992. 163:301–304.
13. Turgut B, Elagoz S, Erselcan T, Koyuncu A, Dokmetas HS, Hasbek Z, Ozdemir S, Aydin C. Preoperative localization of parathyroid adenomas with technetium-99m methoxyisobutylisonitrile imaging: relationship with P-glycoprotein expression, oxyphilic cell content, and tumoral tissue volume. Cancer Biother Radiopharm. 2006. 21:579–590.
14. Nylen E, Shah A, Hall J. Spontaneous remission of primary hyperparathyroidism from parathyroid apoplexy. J Clin Endocrinol Metab. 1996. 81:1326–1328.
15. Kovacs KA, Gay JD. Remission of primary hyperparathyroidism due to spontaneous infarction of a parathyroid adenoma. Case report and review of the literature. Medicine (Baltimore). 1998. 77:398–402.
16. McCoy KL, Yim JH, Zuckerbraun BS, Ogilvie JB, Peel RL, Carty SE. Cystic parathyroid lesions: functional and nonfunctional parathyroid cysts. Arch Surg. 2009. 144:52–56.
17. Lew JI, Solorzano CC, Irvin GL 3rd. Long-term results of parathyroidectomy for hypercalcemic crisis. Arch Surg. 2006. 141:696–699.
18. Bindlish V, Freeman JL, Witterick IJ, Asa SL. Correlation of biochemical parameters with single parathyroid adenoma weight and volume. Head Neck. 2002. 24:1000–1003.
19. Brasier AR, Nussbaum SR. Hungry bone syndrome: clinical and biochemical predictors of its occurrence after parathyroid surgery. Am J Med. 1988. 84:654–660.
20. Piga M, Bolasco P, Satta L, Altieri P, Loi G, Nicolosi A, Tarquini A, Mariotti S. Double phase parathyroid technetium-99m-MIBI scintigraphy to identify functional autonomy in secondary hyperparathyroidism. J Nucl Med. 1996. 37:565–569.
21. Mozes G, Curlee KJ, Rowland CM, van Heerden JA, Thompson GB, Grant CS, Farley DR. The predictive value of laboratory findings in patients with primary hyperparathyroidism. J Am Coll Surg. 2002. 194:126–130.
22. Calva-Cerqueira D, Smith BJ, Hostetler ML, Lal G, Menda Y, O'Dorisio TM, Howe JR. Minimally invasive parathyroidectomy and preoperative MIBI scans: correlation of gland weight and preoperative PTH. J Am Coll Surg. 2007. 205:4 Suppl. S38–S44.
23. Wagner PK, Rothmund M. Correlation of tumor weight and typical pathologic laboratory parameters in primary and secondary hyperparathyroidism. Langenbecks Arch Chir. 1983. 360:133–139.
24. Safran D. Functioning parathyroid cyst. South Med J. 1998. 91:978–980.
25. Fortson JK, Patel VG, Henderson VJ. Parathyroid cysts: a case report and review of the literature. Laryngoscope. 2001. 111:1726–1728.
26. Kataoka K, Taguchi M, Takeshita A, Miyakawa M, Takeuchi Y. Recurrence of primary hyperparathyroidism following spontaneous remission with intracapsular hemorrhage of a parathyroid adenoma. J Bone Miner Metab. 2008. 26:295–297.
27. Wootten CT, Orzeck EA. Spontaneous remission of primary hyperparathyroidism: a case report and meta-analysis of the literature. Head Neck. 2006. 28:81–88.
28. Biertho LD, Kim C, Wu HS, Unger P, Inabnet WB. Relationship between sestamibi uptake, parathyroid hormone assay, and nuclear morphology in primary hyperparathyroidism. J Am Coll Surg. 2004. 199:229–233.
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