Endocrinol Metab.  2011 Mar;26(1):62-66. 10.3803/EnM.2011.26.1.62.

Association of the Parathyroid Adenoma Volume and the Biochemical Parameters in Primary Hyperparathyroidism

• Hwang-Bo Y
• Kim JH
• An JH
• Hong ES
• Ohn JH
• Kim EK
• Khang AR
• Cho SW
• Park DJ
• Park KS
• Kim SY
• Cho BY
• Shin CS

• KMID: 2169126
• DOI: http://doi.org/10.3803/EnM.2011.26.1.62

Abstract

BACKGROUND
The objective of this study is to demonstrate the relationship between the volume of a parathyroid adenoma and the preoperative biochemical parameters in patients undergoing surgery for primary hyperparathyroidism.
METHODS
The medical records of 68 patients who underwent a parathyroidectomy for a single parathyroid adenoma were retrospectively reviewed. The volume of the adenoma was estimated using its measured size and a mathematical formula. The correlation between the volume of the parathyroid adenoma and the preoperative laboratory data was assessed.
RESULTS
There were no correlations between the estimated volume of the adenoma and the serum calcium, alkaline phosphatase and parathyroid hormone levels. However, the volume of the adenoma was associated with the preoperative level of serum phosphorus. After excluding 5 adenomas with cystic degeneration, a positive correlation was noted between the adenoma volume and the preoperative levels of alkaline phosphatase and parathyroid hormone.
CONCLUSION
The preoperative serum levels of calcium, alkaline phosphatase and parathyroid hormone are of limited use to predict the volume of the parathyroid adenoma in patients with a single parathyroid adenoma. We suggest that the absence of a correlation between the volume of the adenoma and the biochemical parameters can be attributed to the cystic degeneration of the adenomas.

Keyword

Hyperparathyroidism; Parathyroid adenoma; Parathyroidectomy

MeSH Terms

Adenoma
Alkaline Phosphatase
Calcium
Humans
Hyperparathyroidism
Hyperparathyroidism, Primary
Medical Records
Parathyroid Hormone
Parathyroid Neoplasms
Parathyroidectomy
Phosphorus
Retrospective Studies
Alkaline Phosphatase
Calcium
Parathyroid Hormone
Phosphorus

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