J Biomed Res.  2014 Dec;15(4):214-219. 10.12729/jbr.2014.15.4.214.

Suspected pituitary gland double adenoma in a cat with insulin-resistant diabetes mellitus

• Park WK
• Kim SG
• Park HM

• KMID: 2169003
• DOI: http://doi.org/10.12729/jbr.2014.15.4.214

Abstract

A 10-year-old castrated male Korean shorthair cat weighing 4 kg was referred with signs of insulin-resistant diabetes mellitus based on clinical signs of polyuria, polydipsia, and polyphagia. Diagnosis of pituitary-dependent hyperadrenocorticism (PDH) was made based on results of an adrenocorticotropic hormone stimulation test and a dexamethasone screening test. In addition, plasma concentrations of insulin-like growth factor 1 (IGF-1) increased. Radiography, ultrasonography, and computed tomography (CT) revealed hepatomegaly, renomegaly, and adrenomegaly affecting both adrenal glands as well as multiple cysts in a generally enlarged pancreas. Magnetic resonance imaging (MRI) showed that the cat's pituitary gland was enlarged. The pituitary gland had a predominantly unilateral extension to the left. The signal intensity of the pituitary gland on precontrast T1 weighted images was hypointense compared to that of soft tissue and hyperintense compared to that of cerebrospinal fluid. On T2 weighted images, the pituitary gland was predominantly hypointense with a hyperintense rim. Contrast enhancement of the pituitary gland was not evident, and a mild degree of ring-like enhancement was seen. In addition, mild peritumoral edema was present. This is the first report of a cat with suspected double adenoma of the pituitary gland on the basis of compatible clinical signs, increased serum IGF-1 concentration, PDH, CT images, and MRI findings in diabetic cats with insulin resistance.

Keyword

cat; insulin-like growth factor 1 (IGF-1); pituitary-dependent hyperadrenocorticism (PDH); magnetic resonance imaging (MRI); acromegaly

MeSH Terms

Acromegaly
Adenoma*
Adrenal Glands
Adrenocortical Hyperfunction
Adrenocorticotropic Hormone
Animals
Cats*
Cerebrospinal Fluid
Child
Dexamethasone
Diabetes Mellitus*
Diagnosis
Edema
Hepatomegaly
Humans
Insulin Resistance
Insulin-Like Growth Factor I
Magnetic Resonance Imaging
Male
Mass Screening
Pancreas
Pituitary Gland*
Plasma
Polydipsia
Polyuria
Radiography
Ultrasonography
Adrenocorticotropic Hormone
Dexamethasone
Insulin-Like Growth Factor I