Allergy Asthma Respir Dis.  2015 May;3(3):224-227. 10.4168/aard.2015.3.3.224.

Apple-dependent exercise-induced anaphylaxis

• Kim DH
• Park KH
• Kim YJ
• Kim JH
• Han HJ
• Park HJ
• Park JW
• Lee JH

• KMID: 2168494
• DOI: http://doi.org/10.4168/aard.2015.3.3.224

Abstract

Food-dependent exercise-induced anaphylaxis (FDEIA) is a specific variant of anaphylaxis that requires both vigorous physical activity and the ingestion of specific causative foods. In particular, occurrence for FDEIA is rarely associated with apples. A 17-year-old male experienced generalized urticaria, dyspnea, headache, vomiting, and presyncope after ingestion of an apple and then 2 hours of exercise. The skin prick test showed a strong positive reaction to apple crude allergen extract, whereas the results of an open food challenge and exercise provocation tests were negative. However, the exercise test after apple consumption provoked a positive reaction with generalized urticaria, dyspnea, and presyncope. We detected 17 kD IgE-reactive protein band in immunoblotting assay with apple crude extract and patient's serum.

Keyword

Anaphylaxis; Food hypersensitivity; Immunoblotting

MeSH Terms

Adolescent
Anaphylaxis*
Dyspnea
Eating
Exercise Test
Food Hypersensitivity
Headache
Humans
Immunoblotting
Male
Malus
Motor Activity
Skin
Syncope
Urticaria
Vomiting

Figure

• 

  Fig. 1 Sodium dodecyl sulfate-polyacrylamide gel electrophoresis and IgE immunoblotting of apple antigen. (A) Negative control, (B) apple allergy patient, and (C) apple dependent exercise induced anaphylaxis patient.

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