Electrolyte Blood Press.  2012 Dec;10(1):26-30. 10.5049/EBP.2012.10.1.26.

Polyuria with the Concurrent manifestation of Central Diabetes Insipidus (CDI) & Type 2 Diabetes Mellitus (DM)

• Shin HJ
• Kim JH
• Yi JH
• Han SW
• Kim HJ

• KMID: 2168391
• DOI: http://doi.org/10.5049/EBP.2012.10.1.26

Abstract

We report a rare case of the concurrent manifestation of central diabetes insipidus (CDI) and type 2 diabetes mellitus (DM). A 56 year-old man was diagnosed as a type 2 DM on the basis of hyperglycemia with polyuria and polydipsia at a local clinic two months ago and started an oral hypoglycemic medication, but resulted in no symptomatic improvement at all. Upon admission to the university hospital, the patient's initial fasting blood sugar level was 140 mg/dL, and he showed polydipsic and polyuric conditions more than 8 L urine/day. Despite the hyperglycemia controlled with metformin and diet, his symptoms persisted. Further investigations including water deprivation test confirmed the coexisting CDI of unknown origin, and the patient's symptoms including an intense thirst were markedly improved by desmopressin nasal spray (10 microg/day). The possibility of a common origin of CDI and type 2 DM is raised in a review of the few relevant adult cases in the literature.

Keyword

Polyuria; Central diabetes insipidus; Type 2 diabetes mellitus; Water deprivation test

MeSH Terms

Adult
Blood Glucose
Deamino Arginine Vasopressin
Diabetes Insipidus, Neurogenic
Diabetes Mellitus, Type 2
Diet
Fasting
Humans
Hyperglycemia
Metformin
Polydipsia
Polyuria
Thirst
Water Deprivation
Blood Glucose
Deamino Arginine Vasopressin
Metformin

Figure

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  Fig. 1 Sagittal dynamic MR images in our patient showing normal enhancement pattern of the straight sinus and of the posterior pituitary.

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