Hanyang Med Rev.  2014 Nov;34(4):153-157. 10.7599/hmr.2014.34.4.153.

Decellularlized Matrix in Organ Transplantation

• Cho CH

• KMID: 2168346
• DOI: http://doi.org/10.7599/hmr.2014.34.4.153

Abstract

Liver transplantation is the only known treatment for patients with end-stage liver failure, but this therapy is limited by the shortage of donor organs. Hepatic tissue engineering combining biomaterial scaffolds and cells have been used as a promising strategy to create engineered liver graft for liver regeneration. Despite significant progress in this field, attempts to create clinically transplantable whole organs have not been as nearly successful. Recently, whole organ decellularization techniques have emerged as a new therapeutic strategy for organ replacement and provided feasibility for clinical translation. The perfusion decellularization method was applied to the whole organ for efficient removal of cellular components and generated organ scaffolds that can maintain the extracellular matrix (ECM) and vascular structure of the native organ. This review paper describes current progress in organ bioengineering for the development of transplantable liver grafts.

Keyword

Liver Transplantation; Hepatic Tissue Engineering; Organ Engineering; Decellularization; Recellularization

MeSH Terms

Bioengineering
Extracellular Matrix
Humans
Liver
Liver Failure
Liver Regeneration
Liver Transplantation
Organ Transplantation*
Perfusion
Tissue Donors
Tissue Engineering
Transplants*

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