Gut Liver.
2012 Jan;6(1):86-91.
Persistence of Protective Hepatitis B Surface Antibody Titers after Successful Double-Dose Hepatitis B Virus Rescue Vaccination in HIV-Infected Patients
- Affiliations
-
- 1Division of Infectious Diseases, Department of Internal Medicine, University of Utah, Salt Lake City, UT, USA.
- 2Department of Infectious Diseases, St. Luke's-Roosevelt Medical Center, Columbia University College of Physicians and Surgeons, New York, NY, USA. gpsevdos@chpnet.org
- 3Center for Comprehensive Care, St. Luke's-Roosevelt Medical Center, Columbia University College of Physicians and Surgeons, New York, NY, USA.
Abstract
- BACKGROUND/AIMS
To assess the durability of protective hepatitis B surface antibody (anti-HBs) titers in HIV-infected patients who responded to double-dose hepatitis B virus (HBV) rescue vaccination.
METHODS
A retrospective chart review was performed for HIV-infected patients who received the double-dose HBV rescue vaccination at 0-, 1-, and 2-month intervals after they had failed conventional HBV vaccination series. A protective antibody response was defined as an anti-HBs titer > or =10 mIU/mL.
RESULTS
Of 54 HIV-infected patients who received a double-dose HBV rescue vaccination, 44 patients (81.5%) had a positive response and achieved protective anti-HB titers. Of the 44 patients who developed protective anti-HB titers, 33 patients received an evaluation of their anti-HB titers 12 months later. Of the 33 patients, 19 (57.6%) had persistent protective anti-HB titers (persistent responders, PR), and 14 patients (42.4%) lost their protective anti-HB titers (nonpersistent responders, NPR). There were significantly more patients who had an undetectable HIV viral load (<50 copies/mL) at baseline and follow-up in the PR group (11/19, 57.9%) than in the NPR group (3/14, 21.4%, p=0.036). Logistic regression analysis showed that an undetectable HIV viral load at baseline and follow-up (odds ratio, 12.973; 95% confidence interval, 1.189 to 141.515; p=0.036) was associated with PR.
CONCLUSIONS
Protective anti-HB titers may decrease over time after successful double-dose HBV rescue vaccination in HIV-infected patients. HIV viral load suppression could improve the persistence of anti-HB titers.
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