Intest Res.  2018 Oct;16(4):599-608. 10.5217/ir.2018.00012.

Response to hepatitis B vaccination in patients with inflammatory bowel disease: a prospective observational study in Korea

Affiliations
  • 1Department of Internal Medicine, Ewha Womans University School of Medicine, Seoul, Korea.

Abstract

BACKGROUND/AIMS
Testing for hepatitis B virus (HBV) serologic markers and appropriate vaccination are required in the management of inflammatory bowel disease (IBD) patients. We evaluated immunogenicity for HBV in IBD patients and the response to the HBV vaccination.
METHODS
From May 2014 to August 2016, patients diagnosed with IBD were prospectively included and evaluated for antibody to hepatitis B surface antigen, antibody to hepatitis B core antigen, and antibody to hepatitis B surface antigen. Among the 73 patients who were confirmed with nonimmunity to HBV, 44 patients who had completed the 3-dose HBV vaccination series received a single booster vaccination, while 29 patients who had not completed the vaccinations series or were unsure of receiving the vaccination received a full vaccination series.
RESULTS
An optimal response was obtained in 70.5% of the patients in the booster group, and 89.7% of the patients in the full vaccination group. Age younger than 26 years (odds ratio [OR], 6.01; 95% confidence interval [CI], 1.15-31.32; P=0.033) and a complete previous vaccination series (OR, 0.15; 95% CI, 0.03-0.80; P=0.026) were associated with optimal vaccine response. Previous complete vaccination series (OR, 0.11; 95% CI, 0.02-0.73; P=0.022) was the only predictive factor for lower compliance.
CONCLUSIONS
The response to the HBV vaccination was lower in patients older than 26 years and for those patients with a complete vaccination history. Since patients with a complete vaccination history also had poor compliance, serum HBV-titers should be checked more thoroughly, and a full vaccination series should be administered in cases when there is a negative response to the booster vaccination.

Keyword

Hepatitis B virus; Vaccination; Inflammatory bowel diseases

MeSH Terms

Compliance
Hepatitis B Core Antigens
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis B*
Hepatitis*
Humans
Inflammatory Bowel Diseases*
Korea*
Observational Study*
Prospective Studies*
Vaccination*
Hepatitis B Core Antigens
Hepatitis B Surface Antigens

Figure

  • Fig. 1. Flowchart of enrolled patients.

  • Fig. 2. Vaccine response in the booster group and full vaccination group.

  • Fig. 3. Evaluation of vaccination response based on serum anti-HBs titer. AIR, adequate immune response defined as anti-HBs titer ≥10 IU/L; EIR, effective immune response defined as anti-HBs titer ≥100 IU/L.

  • Fig. 4. Vaccine response of complete 3-dose vaccination in the patients with inadequate response after booster vaccination.


Cited by  1 articles

Efficacy of hepatitis B vaccination in patients with ulcerative colitis: a prospective cohort study
Anurag Mishra, Amarender Singh Puri, Sanjeev Sachdeva, Ashok Dalal
Intest Res. 2022;20(4):445-451.    doi: 10.5217/ir.2021.00106.


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