Genomics Inform.
2015 Dec;13(4):94-101. 10.5808/GI.2015.13.4.94.
Small Non-coding Transfer RNA-Derived RNA Fragments (tRFs): Their Biogenesis, Function and Implication in Human Diseases
- Affiliations
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- 1Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555, USA. xibao@utmb.edu
- 2miRcore, Ann Arbor, MI 48105, USA.
- 3Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX 77555, USA. yslee@utmb.edu
- 4Sealy Center for Molecular Medicine, University of Texas Medical Branch, Galveston, TX 77555, USA.
- 5The Institute of Translational Science, University of Texas Medical Branch, Galveston, TX 77555, USA.
- 6The Institute for Human Infections & Immunity, University of Texas Medical Branch, Galveston, TX 77555, USA.
- KMID: 2166523
- DOI: http://doi.org/10.5808/GI.2015.13.4.94
Abstract
- tRNA-derived RNA fragments (tRFs) are an emerging class of non-coding RNAs (ncRNAs). A growing number of reports have shown that tRFs are not random degradation products but are functional ncRNAs made of specific tRNA cleavage. They play regulatory roles in several biological contexts such as cancer, innate immunity, stress responses, and neurological disorders. In this review, we summarize the biogenesis and functions of tRFs.
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