Genomics Inform.  2013 Dec;11(4):200-210. 10.5808/GI.2013.11.4.200.

Review of Biological Network Data and Its Applications

• Yu D
• Kim M
• Xiao G
• Hwang TH

• KMID: 2166503
• DOI: http://doi.org/10.5808/GI.2013.11.4.200

Abstract

Studying biological networks, such as protein-protein interactions, is key to understanding complex biological activities. Various types of large-scale biological datasets have been collected and analyzed with high-throughput technologies, including DNA microarray, next-generation sequencing, and the two-hybrid screening system, for this purpose. In this review, we focus on network-based approaches that help in understanding biological systems and identifying biological functions. Accordingly, this paper covers two major topics in network biology: reconstruction of gene regulatory networks and network-based applications, including protein function prediction, disease gene prioritization, and network-based genome-wide association study.

Keyword

biological network; disease gene prioritization; gene regulatory networks; genome-wide association study; protein function prediction; protein-protein interaction

MeSH Terms

Biology
Dataset
Gene Regulatory Networks
Genome-Wide Association Study
Mass Screening
Oligonucleotide Array Sequence Analysis