Genomics Inform.  2007 Mar;5(1):19-23.

Regression Models for Haplotype-Based Association Studies

Affiliations
  • 1Department of Statistics, Seoul National University, Seoul 151-742, Korea. tspark@stats.snu.ac.kr
  • 2Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 151-742, Korea.

Abstract

In this paper, we provide an overview of statistical models for haplotype-based association studies, and summarize their features based on the design matrix. We classify the design matrix into the two types: direct and indirect. For these two kinds of matrices, we present and compare characteristics using a simple hypothetical example, and a real data set. The motivation behind this study was to provide practitioners with an improved understanding, to facilitate the informed selection of the appropriate haplotype-based model and to improve the interpretability of the models.

Keyword

Association; Case-control Study; Design Matrix; Generalized Linear Model; Haplotype

MeSH Terms

Case-Control Studies
Dataset
Haplotypes
Models, Statistical
Motivation
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