Ann Rehabil Med.  2015 Dec;39(6):980-985. 10.5535/arm.2015.39.6.980.

Family History and Functional Outcome in Korean Stroke Patients: A Preliminary Study

Affiliations
  • 1Department of Rehabilitation Medicine, Dankook University College of Medicine, Cheonan, Korea. schola21@gmail.com
  • 2Department of Nanobiomedical Science & WCU Research Center, Dankook University, Cheonan, Korea.
  • 3Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan, Korea.
  • 4Ewha Brain Institute, Ewha Womans University, Seoul, Korea.

Abstract


OBJECTIVE
To investigate the association of family history of stroke with functional outcomes in stroke patients in Korea.
METHODS
A case-control study was conducted. A total of 170 patients who were admitted to a rehabilitation unit were included. Risk factors for stroke such as age, sex, diabetes mellitus, hypertension, atrial fibrillation, smoking, high blood cholesterol and homocysteine level, obesity, and family history of stroke were taken into account. Stroke subtypes were the following: large vessel infarct, small vessel infarct, embolic infarct, subarachnoid hemorrhage, and intracranial hemorrhage. Stroke severity as assessed with the National Institutes of Health Stroke Scale (NIHSS), functional outcomes using the Korean version of the Modified Barthel index (K-MBI), Functional Independence Measurement (FIM), and cognitive function using the Korean version of Mini-Mental State Examination (K-MMSE) were assessed at admission and discharge.
RESULTS
Subjects with a family history of stroke were more likely to have an ischemic stroke (90.7%) than were those without a family history (70.9%). The K-MBI, FIM, NIHSS, and K-MMSE scores did not show significant differences between patients with or without family history.
CONCLUSION
Family history of stroke was significantly associated with ischemic stroke, but not with functional outcomes. Other prognostic factors of stroke were not distributed differently between patients included in this study with or without a family history of stroke.

Keyword

Stroke; Family history; Functional outcome; Prognosis; Ischemic stroke

MeSH Terms

Atrial Fibrillation
Case-Control Studies
Cholesterol
Diabetes Mellitus
Homocysteine
Humans
Hypertension
Intracranial Hemorrhages
Korea
National Institutes of Health (U.S.)
Obesity
Prognosis
Rehabilitation
Risk Factors
Smoke
Smoking
Stroke*
Subarachnoid Hemorrhage
Cholesterol
Homocysteine
Smoke

Reference

1. Graffagnino C, Gasecki AP, Doig GS, Hachinski VC. The importance of family history in cerebrovascular disease. Stroke. 1994; 25:1599–1604. PMID: 8042210.
Article
2. Jerrard-Dunne P, Cloud G, Hassan A, Markus HS. Evaluating the genetic component of ischemic stroke subtypes: a family history study. Stroke. 2003; 34:1364–1369. PMID: 12714707.
3. Jood K, Ladenvall C, Rosengren A, Blomstrand C, Jern C. Family history in ischemic stroke before 70 years of age: the Sahlgrenska Academy Study on Ischemic Stroke. Stroke. 2005; 36:1383–1387. PMID: 15933254.
4. Aycock DM, Kirkendoll KD, Coleman KC, Clark PC, Albright KC, Alexandrov AW. Family history of stroke among African Americans and its association with risk factors, knowledge, perceptions, and exercise. J Cardiovasc Nurs. 2015; 30:E1–E6. PMID: 24598552.
Article
5. Debette S, Goeggel Simonetti B, Schilling S, Martin JJ, Kloss M, Sarikaya H, et al. Familial occurrence and heritable connective tissue disorders in cervical artery dissection. Neurology. 2014; 83:2023–2031. PMID: 25355833.
Article
6. O'Neill SM, Rubinstein WS, Wang C, Yoon PW, Acheson LS, Rothrock N, et al. Familial risk for common diseases in primary care: the Family Healthware Impact Trial. Am J Prev Med. 2009; 36:506–514. PMID: 19460658.
7. Lisabeth LD, Smith MA, Brown DL, Uchino K, Morgenstern LB. Family history and stroke outcome in a bi-ethnic, population-based stroke surveillance study. BMC Neurol. 2005; 5:20. PMID: 16262890.
Article
8. Morgenstern LB, Smith MA, Lisabeth LD, Risser JM, Uchino K, Garcia N, et al. Excess stroke in Mexican Americans compared with non-Hispanic Whites: the Brain Attack Surveillance in Corpus Christi Project. Am J Epidemiol. 2004; 160:376–383. PMID: 15286023.
Article
9. Harmsen P, Lappas G, Rosengren A, Wilhelmsen L. Long-term risk factors for stroke: twenty-eight years of follow-up of 7457 middle-aged men in Goteborg, Sweden. Stroke. 2006; 37:1663–1667. PMID: 16728686.
10. Mi D, Zhang L, Wang C, Liu L, Pu Y, Zhao X, et al. Impact of metabolic syndrome on the prognosis of ischemic stroke secondary to symptomatic intracranial atherosclerosis in Chinese patients. PLoS One. 2012; 7:e51421. PMID: 23251528.
Article
11. Genetics Home Reference. First-degree relative [Internet]. Bethesda: Genomics Home Reference, National Library of Medicine;2015. cited 2015 Nov 10. Available from: http://ghr.nlm.nih.gov/glossary=firstdegreerelative.
12. Mohr JP, Caplan LR, Melski JW, Goldstein RJ, Duncan GW, Kistler JP, et al. The Harvard Cooperative Stroke Registry: a prospective registry. Neurology. 1978; 28:754–762. PMID: 567291.
Article
13. Goldstein LB, Samsa GP. Reliability of the National Institutes of Health Stroke Scale: extension to nonneurologists in the context of a clinical trial. Stroke. 1997; 28:307–310. PMID: 9040680.
14. Jung HY, Park BK, Shin HS, Kang YK, Pyun SB, Paik NJ, et al. Development of the Korean version of Modified Barthel Index (K-MBI): multi-center study for subjects with stroke. J Korean Acad Rehabil Med. 2007; 31:283–297.
15. Hamilton BB, Laughlin JA, Fiedler RC, Granger CV. Interrater reliability of the 7-level functional independence measure (FIM). Scand J Rehabil Med. 1994; 26:115–119. PMID: 7801060.
16. Park JH. Modification of the mini-mental state examination for use in the elderly in a non-western society. Part 1: Development of Korean version of mini-mental state examination. Int J Geriatr Psychiatry. 1990; 5:381–387.
Article
17. Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell. 2001; 104:545–556. PMID: 11239411.
Article
18. Palatini P. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. JAMA. 2004; 292:1174–1175. PMID: 15353527.
Article
19. O'Donnell CJ, Nabel EG. Genomics of cardiovascular disease. N Engl J Med. 2011; 365:2098–2109. PMID: 22129254.
20. Markus HS, Khan U, Birns J, Evans A, Kalra L, Rudd AG, et al. Differences in stroke subtypes between black and white patients with stroke: the South London Ethnicity and Stroke Study. Circulation. 2007; 116:2157–2164. PMID: 17967776.
21. Adams HP Jr, Bendixen BH, Kappelle LJ, Biller J, Love BB, Gordon DL, et al. Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment. Stroke. 1993; 24:35–41. PMID: 7678184.
Article
22. Polychronopoulos P, Gioldasis G, Ellul J, Metallinos IC, Lekka NP, Paschalis C, et al. Family history of stroke in stroke types and subtypes. J Neurol Sci. 2002; 195:117–122. PMID: 11897241.
Article
23. Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nat Rev Neurosci. 2009; 10:861–872. PMID: 19888284.
Article
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