Exp Neurobiol.
2012 Mar;21(1):9-15. 10.5607/en.2012.21.1.9.
Neuronal Functions of ESCRTs
- Affiliations
-
- 1Department of Biotechnology, College of Life Science and Nano Technology, Hannam University, Dajeon 305-811, Korea. leeja@hnu.kr
- 2Department of Neurology, University of Massachusetts Medical School, Worcester, Massachusetts, 01605 USA.
- KMID: 2165385
- DOI: http://doi.org/10.5607/en.2012.21.1.9
Abstract
- The endosomal sorting complexes required for transport (ESCRTs) regulate protein trafficking from endosomes to lysosomes. Recent studies have shown that ESCRTs are involved in various cellular processes, including membrane scission, microRNA function, viral budding, and the autophagy pathway in many tissues, including the nervous system. Indeed, dysfunctional ESCRTs are associated with neurodegeneration. However, it remains largely elusive how ESCRTs act in post-mitotic neurons, a highly specialized cell type that requires dynamic changes in neuronal structures and signaling for proper function. This review focuses on our current understandings of the functions of ESCRTs in neuronal morphology, synaptic plasticity, and neurodegenerative diseases.
Keyword
- Full Text Links
-
- Actions
-
Cited
- CITED
-
- Close
- Share
-
- Similar articles
-
- Impaired Cholesterol Metabolism, Neurons, and Neuropsychiatric Disorders
- From Bound Cells Comes a Sound Mind: The Role of Neuronal Growth Regulator 1 in Psychiatric Disorders
- Somatic mutations in disorders with disrupted brain connectivity
- Evaluation of the Relationships between Irisin Levels and Cognitive Functions in Individuals with Schizophrenia
- Blunted Peripheral and Central Responses to Gastric Mechanical and Electrical Stimulations in Diet-induced Obese Rats
