Allergy.  1994 Jun;14(2):199-208.

A Comparison Study on Soluble Fc epsilon R II/CD23,(IL-4) and IFN-gammaActivities in the Serum of Children with Atopic and Nonatopic Disease

• Park IC
• Lee HB

Abstract

Elevated levels of serum IgE are a major immunological abnormality in the atopic disease. Cytokines specifically regulating IgE synthesis have been postulated for many years. The soluble fragment of CD23, are able to synergize with IL4 for promoting IgE synthesis, while IFN-gammahas the antagonistic effect. We studied the production of sCD23, IL-4 and IFN-gammato assess that T cell factor regulation of IgE synthesis in the atopic children differ from that nonatopic subjects, by measuring cytokine concentrations in serum collected from 10 stable atopic asthmatics, 3 chidren with active autoimmune disease including and rheumatoid arthritis, and 4 healthy chidren without allergic and/or acute inflammatory disease The results of study were as follows: 1. The mean ages of study groups were as follows:asthmatics, 9.6 years;nonatopic disease group, 8.7 years;healthy control, 10.6 years. 2. The serum IgE values were higher in the asthmatics than in control (p = 0.038). 3. The serum concentration of sCD23 in the asthmatics were not significantly higher than contro] group, but there was a tendency that sCD23 in nonatopic disease were higher than control (p=0.018). 4. The activities of IL 4 in the serum varied regardless of the age of study subjects, and significant difference in the activities was not observed between the study groups and the control. 5. The levels of IFN-gammawere higher in the asthmatics than in the control group(p<0.05) and nonatopic disease, owing to the potential production of IFN-gammain the stable phase of asthmatics. 6. There was no significant correlation between the levels of the cytokines and IgE in both disease groups, but the relevant increase in IL-4 and IgE was observed in asthmatics. In conclusion, these results suggested that sCD23, IL 4 and INF-gammamight play a role in, in vivo, IgE synthesis.

MeSH Terms

Arthritis, Rheumatoid
Autoimmune Diseases
Child*
Cytokines
Humans
Immunoglobulin E
Interleukin-4
Cytokines
Immunoglobulin E
Interleukin-4