Allergy Asthma Respir Dis.  2016 May;4(3):174-180. 10.4168/aard.2016.4.3.174.

Clinical characteristics of interferon-gamma-inducible protein of 10 kDa in children with wheezing

• Kim BJ
• Bae KS
• Kim HS
• Chun YH
• Yoon JS
• Kim HH
• Kim JT

• KMID: 2165078
• DOI: http://doi.org/10.4168/aard.2016.4.3.174

Abstract

PURPOSE
Recent studies have shown that interferon-gamma-inducible protein of 10 kDa (IP-10/CXCL10) levels is increased in acute bronchiolitis and asthma. The aim of this study was to examine the levels of IP-10 in children with wheezing and whether it correlates with other clinical variables.
METHODS
A total of 62 subjects children were hospitalized for lower respiratory tract infection with wheezing and visited the Emergency Department due to an acute exacerbation of asthma. IP-10 levels were measured using enzyme-linked immunosorbent assay in the serum collected at admission. Serum IP-10 levels were evaluated for the relationships with age, sex, blood eosinophils counts, acute phase reactant, allergic sensitization, history of wheezing, and chest X-ray findings.
RESULTS
Age showed a significant negative correlation with serum IP-10 levels (P=0.002). The serum levels of IP-10 were also significantly increased in patients with pneumonic infiltration on X-rays compared to those with normal or hyperinflation (P<0.009). There was no significant difference in the serum IP-10 level according to the other factors, including allergic sensitization.
CONCLUSION
Serum IP-10 is significantly associated with inflammation of the lung and age, but not with allergic inflammation.

Keyword

Interferon-gamma-inducible protein of 10 kDa; Wheezing; Child

MeSH Terms

Asthma
Bronchiolitis
Chemokine CXCL10*
Child*
Emergency Service, Hospital
Enzyme-Linked Immunosorbent Assay
Eosinophils
Humans
Inflammation
Lung
Respiratory Sounds*
Respiratory Tract Infections
Thorax
Chemokine CXCL10

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