Ann Dermatol.  2001 Mar;13(1):28-31. 10.5021/ad.2001.13.1.28.

The Ivory Colored Hypopigmentation After Autologous Suction Blister Grafts in Vitiligo Lesion May be Caused by the Pretreated Deep Freeze

• Suh JC
• Yeum JS
• Seo SK
• Na GY

• KMID: 2163856
• DOI: http://doi.org/10.5021/ad.2001.13.1.28

Abstract

BACKGROUND
Ivory colored hypopigmentation has been frequently observed in morphea and lichen sclerosus et atrophicus, and also seen after phenol peels, dermabrasion, cryosurgery and post-laser resurfacing.
OBJECTIVE
This study was undertaken to investigate the cause of hypopigmentation following autologous suction blister graft (ASBG) in vitiligo patients.
METHODS
The ivory lesion and contralateral normal skin were collected by punch biopsies. And the tissues were stained with hematoxylin-eosin, Fontana-Masson, Masson's trichrome, Verhoeff-van Gieson, and S-100 protein to compare the differences between two specimens.
RESULTS
H-E and Masson's Trichrome stains showed that compacted hyalinized sclerotic collagens and collapsed, small sized capillaries in the upper dermis were definite in the hypopigmented lesion, whereas norma1 control sites were unremarkable. Elastic fibers were markedly decreased or fragmented in upper dermis of the hypopigmented lesion. Fontanna-Masson stain identified that the lesional epidermis was more hyperpigmented rather than hypopigmented. S-100 stain showed no differences between hypopigmented and contro1 sites.
CONCLUSION
The results suggest that the ivory colored hypopigmentation is not caused by the failure of procedure, but by scar formation due to deep freeze; therefore, this kind of complication may be prevented by carefully performing the cryotherapy.

Keyword

Vitiligo; Autologous suction blister graft; Ivory hypopigmentation; Cryotherapy

MeSH Terms

Biopsy
Blister*
Capillaries
Cicatrix
Collagen
Coloring Agents
Cryosurgery
Cryotherapy
Dermabrasion
Dermis
Elastic Tissue
Epidermis
Humans
Hyalin
Hypopigmentation*
Lichen Sclerosus et Atrophicus
Phenol
S100 Proteins
Scleroderma, Localized
Skin
Suction*
Transplants*
Vitiligo*
Collagen
Coloring Agents
Phenol
S100 Proteins