Ann Dermatol.  2001 Mar;13(1):12-15. 10.5021/ad.2001.13.1.12.

The Efficacy of Cyclosporin in Patients with Severe Atopic Dermatitis

• Lee JH
• Kim KH
• Park KC
• Chung JH
• Suh DH

• KMID: 2163853
• DOI: http://doi.org/10.5021/ad.2001.13.1.12

Abstract

BACKGROUND
Cyclosporin A (CsA), a potent immunosuppressant, has been reported to be effective in the treatment of severe atopic dermatitis (AD).
OBJECTIVE
The aim of this study was to evaluate the efficacy and side-effects of CsA in Korean patients with severe AD.
MATERIALS AND METHODS
16 patients with recalcitrant AD took CsA for at least 6 weeks. Among them, 11 patients were followed up for more than 16 weeks. Initial dose was 5mg/kg/day (maximum 300 mg/day) and the dose was reduced according to their therapeutic responses. SCORAD (Scoring AD) was used to evaluate clinical efficacy of CsA. During the 1st month of therapy, the therapeutic efficacy and side-effects were evaluated every 2weeks and after 1 month, every month. We checked blood pressure and laboratory abnormalities including liver function test, blood urea nitrogen (BUN), creatinine (Cr) and urinalysis at each visit in addition to observing clinical adverse effects.
RESULTS
Significant reduction of SCORAD was noted in 15 patients after 6 weeks of CsA therapy. Only one patient stopped CsA therapy because of the elevation of blood pressure. Three patients showed albuminuria, which disappeared after CsA dose reduction.
CONCLUSION
CsA can be used effectively and safely in severe Korean AD patients. Albuminuria seems to be a peculiar side-effect in Korean patients.

Keyword

Cyclosporin A; Therapeutic efficacy; Side-effects

MeSH Terms

Albuminuria
Blood Pressure
Blood Urea Nitrogen
Creatinine
Cyclosporine*
Dermatitis, Atopic*
Humans
Liver Function Tests
Urinalysis
Creatinine
Cyclosporine