Korean J Med.  2016 May;90(5):369-377. 10.3904/kjm.2016.90.5.369.

Cancer-associated Kidney Disease

• Lee JE

• KMID: 2163228
• DOI: http://doi.org/10.3904/kjm.2016.90.5.369

Abstract

Kidney disease is common in patients with cancer and includes diseases that occur in people without cancer. In addition, certain kidney disorders are related to either cancer therapy or the malignancy itself. Paraneoplastic glomerulonephritis and post-hematopoietic stem-cell transplantation kidney disease (thrombotic microangiopathy, veno-occlusive disease, and kidney injury from graft-versus-host disease) are prime examples. Newer cancer therapy has increased cancer cure rates and survival times, but nephrotoxicity remains an important complication of chemotherapy. Consequently, patients with cancer are at increased risk of developing acute kidney injury, chronic kidney disease, and fluid and electrolyte abnormalities. In patients with chronic kidney disease, therapeutic doses may need to be reduced. Therefore, it is essential that nephrologists be informed and involved in cancer care. Nephrologists must provide expertise in the evaluation and management of acute and chronic kidney disease, fluid and electrolyte disorders, and the use of various extracorporeal therapies in patients with cancer. Additionally, onco-nephrologists, who must be knowledgeable about the array of new chemotherapeutic agents and their potential effects on kidney function, are needed to provide integral care for patients with cancer.

Keyword

Nephrology; Neoplasms; Antineoplastic agents; Drug-related side effects and adverse reactions

MeSH Terms

Acute Kidney Injury
Antineoplastic Agents
Drug Therapy
Drug-Related Side Effects and Adverse Reactions
Glomerulonephritis
Humans
Kidney Diseases*
Kidney*
Nephrology
Renal Insufficiency, Chronic
Antineoplastic Agents