J Korean Hip Soc.  2008 Dec;20(4):320-325. 10.5371/jkhs.2008.20.4.320.

The Expression of Extracellular Matrix mRNA in the Chondrocytes of the Femoral Head Affected by Avascular Necrosis

• Chung WY
• Lee WS
• Kim SB
• Bae IT
• Park WK

• KMID: 2162618
• DOI: http://doi.org/10.5371/jkhs.2008.20.4.320

Abstract

PURPOSE
The aim of this study was to evaluate the expression of type II collagen, aggrecan, VEGF-A and PEDF mRNAs in the human chondrocytes derived from the articular cartilage of the femoral heads with avacular necrosis (AVN).
MATERIALS AND METHODS
We cultured human chondrocytes that were primarily derived from the articular cartilage of femoral heads with AVN. We evaluated the mRNA expression of type II collagen, aggrecan, VEGF-A and PEDF.
RESULTS
The chondrocytes of the AVN group showed decreased expressions of type II collagen mRNA and aggrecan mRNA (p<0.05). The expression of VEGF-A mRNA and PEDF mRNA in the AVN group was the same as that of the normal group (p>0.05).
CONCLUSION
The cartilage matrix's formation ability was found to be decreased in the chondrocytes of the femoral heads affected by AVN.

Keyword

Avacular necrosis; Chondrocytes; Type II collagen; Aggrecan; VEGF-A; PEDF

MeSH Terms

Aggrecans
Cartilage
Cartilage, Articular
Chondrocytes
Collagen Type II
Extracellular Matrix
Head
Humans
Necrosis
RNA, Messenger
Vascular Endothelial Growth Factor A
Aggrecans
Collagen Type II
RNA, Messenger
Vascular Endothelial Growth Factor A